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Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer
I report a case of multiple organ failure (acute kidney injury, interstitial pneumonitis and liver dysfunction) associated with combined androgen blockade(CAB) with bicalutamide and leuprorelin acetate for prostate cancer that was successfully managed by prompt hemodialysis and withdrawal of medicat...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951477/ https://www.ncbi.nlm.nih.gov/pubmed/31934548 http://dx.doi.org/10.1016/j.eucr.2019.101108 |
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author | Saito, Seiichi |
author_facet | Saito, Seiichi |
author_sort | Saito, Seiichi |
collection | PubMed |
description | I report a case of multiple organ failure (acute kidney injury, interstitial pneumonitis and liver dysfunction) associated with combined androgen blockade(CAB) with bicalutamide and leuprorelin acetate for prostate cancer that was successfully managed by prompt hemodialysis and withdrawal of medications. Finally, patient received orchiectomy for the treatment of prostate cancer, and the histology of renal biopsy revealed drug-induced tubulointerstitial nephritis. Although the condition is extremely rare, urologists should be aware of CAB-induced organ failures such as those of the lung, kidney and liver. It should also be noted that urologists should not initially prescribe long-acting Gn-RH. |
format | Online Article Text |
id | pubmed-6951477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69514772020-01-13 Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer Saito, Seiichi Urol Case Rep Oncology I report a case of multiple organ failure (acute kidney injury, interstitial pneumonitis and liver dysfunction) associated with combined androgen blockade(CAB) with bicalutamide and leuprorelin acetate for prostate cancer that was successfully managed by prompt hemodialysis and withdrawal of medications. Finally, patient received orchiectomy for the treatment of prostate cancer, and the histology of renal biopsy revealed drug-induced tubulointerstitial nephritis. Although the condition is extremely rare, urologists should be aware of CAB-induced organ failures such as those of the lung, kidney and liver. It should also be noted that urologists should not initially prescribe long-acting Gn-RH. Elsevier 2019-12-19 /pmc/articles/PMC6951477/ /pubmed/31934548 http://dx.doi.org/10.1016/j.eucr.2019.101108 Text en © 2019 The Author http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Oncology Saito, Seiichi Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer |
title | Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer |
title_full | Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer |
title_fullStr | Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer |
title_full_unstemmed | Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer |
title_short | Successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer |
title_sort | successful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951477/ https://www.ncbi.nlm.nih.gov/pubmed/31934548 http://dx.doi.org/10.1016/j.eucr.2019.101108 |
work_keys_str_mv | AT saitoseiichi successfulrecoveryfrommultipleorganfailureassociatedwithbicalutamideandleuprorelinacetateforprostatecancer |