Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice

Late onset Alzheimer’s disease (LOAD) is a progressive neurodegenerative disease with four well-established risk factors: age, APOE4 genotype, female chromosomal sex, and maternal history of AD. Each risk factor impacts multiple systems, making LOAD a complex systems biology challenge. To investigat...

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Detalles Bibliográficos
Autores principales: Shang, Yuan, Mishra, Aarti, Wang, Tian, Wang, Yiwei, Desai, Maunil, Chen, Shuhua, Mao, Zisu, Do, Loi, Bernstein, Adam S., Trouard, Theodore P., Brinton, Roberta D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952084/
https://www.ncbi.nlm.nih.gov/pubmed/31917799
http://dx.doi.org/10.1371/journal.pone.0225392

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