Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice

Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-specific, conditional expression of murine IL11 in a...

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Detalles Bibliográficos
Autores principales: Lim, Wei-Wen, Ng, Benjamin, Widjaja, Anissa, Xie, Chen, Su, Liping, Ko, Nicole, Lim, Sze-Yun, Kwek, Xiu-Yi, Lim, Stella, Cook, Stuart Alexander, Schafer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952089/
https://www.ncbi.nlm.nih.gov/pubmed/31917819
http://dx.doi.org/10.1371/journal.pone.0227505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952089/
https://www.ncbi.nlm.nih.gov/pubmed/31917819
http://dx.doi.org/10.1371/journal.pone.0227505

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