A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

Adult mammalian brains have largely lost neuroregeneration capability except for a few niches. Previous studies have converted glial cells into neurons, but the total number of neurons generated is limited and the therapeutic potential is unclear. Here, we demonstrate that NeuroD1-mediated in situ a...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Chen, Ma, Ning-Xin, Pei, Zi-Fei, Wu, Zheng, Do-Monte, Fabricio H., Keefe, Susan, Yellin, Emma, Chen, Miranda S., Yin, Jiu-Chao, Lee, Grace, Minier-Toribio, Angélica, Hu, Yi, Bai, Yu-Ting, Lee, Kathryn, Quirk, Gregory J., Chen, Gong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952185/
https://www.ncbi.nlm.nih.gov/pubmed/31551137
http://dx.doi.org/10.1016/j.ymthe.2019.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952185/
https://www.ncbi.nlm.nih.gov/pubmed/31551137
http://dx.doi.org/10.1016/j.ymthe.2019.09.003

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