Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model

Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures...

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Autores principales: Wong, Sarah Sze Wah, Krylov, Vadim B., Argunov, Dmitry A., Karelin, Alexander A., Bouchara, Jean-Phillipe, Fontaine, Thierry, Latgé, Jean-Paul, Nifantiev, Nikolay E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Opinion/Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952192/
https://www.ncbi.nlm.nih.gov/pubmed/31915215
http://dx.doi.org/10.1128/mSphere.00688-19
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author Wong, Sarah Sze Wah
Krylov, Vadim B.
Argunov, Dmitry A.
Karelin, Alexander A.
Bouchara, Jean-Phillipe
Fontaine, Thierry
Latgé, Jean-Paul
Nifantiev, Nikolay E.
author_facet Wong, Sarah Sze Wah
Krylov, Vadim B.
Argunov, Dmitry A.
Karelin, Alexander A.
Bouchara, Jean-Phillipe
Fontaine, Thierry
Latgé, Jean-Paul
Nifantiev, Nikolay E.
author_sort Wong, Sarah Sze Wah
collection PubMed
description Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.
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spelling pubmed-69521922020-01-16 Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model Wong, Sarah Sze Wah Krylov, Vadim B. Argunov, Dmitry A. Karelin, Alexander A. Bouchara, Jean-Phillipe Fontaine, Thierry Latgé, Jean-Paul Nifantiev, Nikolay E. mSphere Opinion/Hypothesis Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide. American Society for Microbiology 2020-01-08 /pmc/articles/PMC6952192/ /pubmed/31915215 http://dx.doi.org/10.1128/mSphere.00688-19 Text en Copyright © 2020 Wong et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Opinion/Hypothesis
Wong, Sarah Sze Wah
Krylov, Vadim B.
Argunov, Dmitry A.
Karelin, Alexander A.
Bouchara, Jean-Phillipe
Fontaine, Thierry
Latgé, Jean-Paul
Nifantiev, Nikolay E.
Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
title Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
title_full Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
title_fullStr Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
title_full_unstemmed Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
title_short Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
title_sort potential of chemically synthesized oligosaccharides to define the carbohydrate moieties of the fungal cell wall responsible for the human immune response, using aspergillus fumigatus galactomannan as a model
topic Opinion/Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952192/
https://www.ncbi.nlm.nih.gov/pubmed/31915215
http://dx.doi.org/10.1128/mSphere.00688-19
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