Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway

The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance. A promising strategy to overcome these drawbacks is to combine echinocandins...

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Detalles Bibliográficos
Autores principales: Tripathi, Siddharth K., Feng, Qin, Liu, Li, Levin, David E., Roy, Kuldeep K., Doerksen, Robert J., Baerson, Scott R., Shi, Xiaomin, Pan, Xuewen, Xu, Wen-Hui, Li, Xing-Cong, Clark, Alice M., Agarwal, Ameeta K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952202/
https://www.ncbi.nlm.nih.gov/pubmed/31915228
http://dx.doi.org/10.1128/mSphere.00818-19

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