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Diagnosing coeliac disease: Out with the old and in with the new?
Coeliac disease (CD) is a complex condition resulting from an interplay between genetic and environmental factors. When diagnosing the condition, serological testing and genotyping are useful in excluding CD, although the gold standard of testing is currently histopathological examination of the sma...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952296/ https://www.ncbi.nlm.nih.gov/pubmed/31933510 http://dx.doi.org/10.3748/wjg.v26.i1.1 |
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author | Charlesworth, Richard PG |
author_facet | Charlesworth, Richard PG |
author_sort | Charlesworth, Richard PG |
collection | PubMed |
description | Coeliac disease (CD) is a complex condition resulting from an interplay between genetic and environmental factors. When diagnosing the condition, serological testing and genotyping are useful in excluding CD, although the gold standard of testing is currently histopathological examination of the small intestine. There are drawbacks associated with this form of testing however and because of this, novel forms of testing are currently under investigation. Before we develop completely novel tests though, it is important to ask whether or not we can simply use the data we gather from coeliac patients more effectively and build a more accurate snapshot of CD through statistical analysis of combined metrics. It is clear that not one single test can accurately diagnose CD and it is also clear that CD patients can no longer be defined by discrete classifications, the continuum of patient presentation needs to be recognised and correctly captured to improve diagnostic accuracy. This review will discuss the current diagnostics for CD and then outline novel diagnostics under investigation for the condition. Finally, improvements to current protocols will be discussed with the need for a holistic “snapshot” of CD using a number of metrics simultaneously. |
format | Online Article Text |
id | pubmed-6952296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-69522962020-01-13 Diagnosing coeliac disease: Out with the old and in with the new? Charlesworth, Richard PG World J Gastroenterol Opinion Review Coeliac disease (CD) is a complex condition resulting from an interplay between genetic and environmental factors. When diagnosing the condition, serological testing and genotyping are useful in excluding CD, although the gold standard of testing is currently histopathological examination of the small intestine. There are drawbacks associated with this form of testing however and because of this, novel forms of testing are currently under investigation. Before we develop completely novel tests though, it is important to ask whether or not we can simply use the data we gather from coeliac patients more effectively and build a more accurate snapshot of CD through statistical analysis of combined metrics. It is clear that not one single test can accurately diagnose CD and it is also clear that CD patients can no longer be defined by discrete classifications, the continuum of patient presentation needs to be recognised and correctly captured to improve diagnostic accuracy. This review will discuss the current diagnostics for CD and then outline novel diagnostics under investigation for the condition. Finally, improvements to current protocols will be discussed with the need for a holistic “snapshot” of CD using a number of metrics simultaneously. Baishideng Publishing Group Inc 2020-01-07 2020-01-07 /pmc/articles/PMC6952296/ /pubmed/31933510 http://dx.doi.org/10.3748/wjg.v26.i1.1 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Opinion Review Charlesworth, Richard PG Diagnosing coeliac disease: Out with the old and in with the new? |
title | Diagnosing coeliac disease: Out with the old and in with the new? |
title_full | Diagnosing coeliac disease: Out with the old and in with the new? |
title_fullStr | Diagnosing coeliac disease: Out with the old and in with the new? |
title_full_unstemmed | Diagnosing coeliac disease: Out with the old and in with the new? |
title_short | Diagnosing coeliac disease: Out with the old and in with the new? |
title_sort | diagnosing coeliac disease: out with the old and in with the new? |
topic | Opinion Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952296/ https://www.ncbi.nlm.nih.gov/pubmed/31933510 http://dx.doi.org/10.3748/wjg.v26.i1.1 |
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