Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals’ Body Mass Index (BMI) or blood volume (BV) might affect its correlation to...

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Autores principales: Manouchehrinia, Ali, Piehl, Fredrik, Hillert, Jan, Kuhle, Jens, Alfredsson, Lars, Olsson, Tomas, Kockum, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952306/
https://www.ncbi.nlm.nih.gov/pubmed/31893563
http://dx.doi.org/10.1002/acn3.50972
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author Manouchehrinia, Ali
Piehl, Fredrik
Hillert, Jan
Kuhle, Jens
Alfredsson, Lars
Olsson, Tomas
Kockum, Ingrid
author_facet Manouchehrinia, Ali
Piehl, Fredrik
Hillert, Jan
Kuhle, Jens
Alfredsson, Lars
Olsson, Tomas
Kockum, Ingrid
author_sort Manouchehrinia, Ali
collection PubMed
description Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals’ Body Mass Index (BMI) or blood volume (BV) might affect its correlation to other biomarkers and disease outcomes. Here, we investigated the correlation between plasma NfL, BMI, and BV in 662 controls and 2,586 multiple sclerosis cases. We found a significant negative correlation between plasma NfL, BMI/BV in both groups. Our results highlight the potential confounding effect of BMI/BV on associations between blood NfL and disease outcomes.
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spelling pubmed-69523062020-01-10 Confounding effect of blood volume and body mass index on blood neurofilament light chain levels Manouchehrinia, Ali Piehl, Fredrik Hillert, Jan Kuhle, Jens Alfredsson, Lars Olsson, Tomas Kockum, Ingrid Ann Clin Transl Neurol Brief Communications Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals’ Body Mass Index (BMI) or blood volume (BV) might affect its correlation to other biomarkers and disease outcomes. Here, we investigated the correlation between plasma NfL, BMI, and BV in 662 controls and 2,586 multiple sclerosis cases. We found a significant negative correlation between plasma NfL, BMI/BV in both groups. Our results highlight the potential confounding effect of BMI/BV on associations between blood NfL and disease outcomes. John Wiley and Sons Inc. 2020-01-01 /pmc/articles/PMC6952306/ /pubmed/31893563 http://dx.doi.org/10.1002/acn3.50972 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Manouchehrinia, Ali
Piehl, Fredrik
Hillert, Jan
Kuhle, Jens
Alfredsson, Lars
Olsson, Tomas
Kockum, Ingrid
Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
title Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
title_full Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
title_fullStr Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
title_full_unstemmed Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
title_short Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
title_sort confounding effect of blood volume and body mass index on blood neurofilament light chain levels
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952306/
https://www.ncbi.nlm.nih.gov/pubmed/31893563
http://dx.doi.org/10.1002/acn3.50972
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