First FHM3 mouse model shows spontaneous cortical spreading depolarizations

Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1...

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Detalles Bibliográficos
Autores principales: Jansen, Nico A., Dehghani, Anisa, Linssen, Margot M. L., Breukel, Cor, Tolner, Else A., van den Maagdenberg, Arn M. J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952313/
https://www.ncbi.nlm.nih.gov/pubmed/31880072
http://dx.doi.org/10.1002/acn3.50971
Descripción
Sumario:Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1 subunits in voltage‐gated Na(V)1.1 sodium channels (Scn1a (L263V)). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.

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