First FHM3 mouse model shows spontaneous cortical spreading depolarizations

Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1...

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Autores principales: Jansen, Nico A., Dehghani, Anisa, Linssen, Margot M. L., Breukel, Cor, Tolner, Else A., van den Maagdenberg, Arn M. J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952313/
https://www.ncbi.nlm.nih.gov/pubmed/31880072
http://dx.doi.org/10.1002/acn3.50971
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author Jansen, Nico A.
Dehghani, Anisa
Linssen, Margot M. L.
Breukel, Cor
Tolner, Else A.
van den Maagdenberg, Arn M. J. M.
author_facet Jansen, Nico A.
Dehghani, Anisa
Linssen, Margot M. L.
Breukel, Cor
Tolner, Else A.
van den Maagdenberg, Arn M. J. M.
author_sort Jansen, Nico A.
collection PubMed
description Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1 subunits in voltage‐gated Na(V)1.1 sodium channels (Scn1a (L263V)). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.
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spelling pubmed-69523132020-01-10 First FHM3 mouse model shows spontaneous cortical spreading depolarizations Jansen, Nico A. Dehghani, Anisa Linssen, Margot M. L. Breukel, Cor Tolner, Else A. van den Maagdenberg, Arn M. J. M. Ann Clin Transl Neurol Brief Communications Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1 subunits in voltage‐gated Na(V)1.1 sodium channels (Scn1a (L263V)). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature. John Wiley and Sons Inc. 2019-12-27 /pmc/articles/PMC6952313/ /pubmed/31880072 http://dx.doi.org/10.1002/acn3.50971 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Jansen, Nico A.
Dehghani, Anisa
Linssen, Margot M. L.
Breukel, Cor
Tolner, Else A.
van den Maagdenberg, Arn M. J. M.
First FHM3 mouse model shows spontaneous cortical spreading depolarizations
title First FHM3 mouse model shows spontaneous cortical spreading depolarizations
title_full First FHM3 mouse model shows spontaneous cortical spreading depolarizations
title_fullStr First FHM3 mouse model shows spontaneous cortical spreading depolarizations
title_full_unstemmed First FHM3 mouse model shows spontaneous cortical spreading depolarizations
title_short First FHM3 mouse model shows spontaneous cortical spreading depolarizations
title_sort first fhm3 mouse model shows spontaneous cortical spreading depolarizations
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952313/
https://www.ncbi.nlm.nih.gov/pubmed/31880072
http://dx.doi.org/10.1002/acn3.50971
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