Image-guided neural activity manipulation with a paramagnetic drug

Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed...

Descripción completa

Detalles Bibliográficos
Autores principales: Bricault, Sarah, Barandov, Ali, Harvey, Peter, DeTienne, Elizabeth, Hai, Aviad, Jasanoff, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952355/
https://www.ncbi.nlm.nih.gov/pubmed/31919353
http://dx.doi.org/10.1038/s41467-019-13933-5
Descripción
Sumario:Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.

Ejemplares similares