Image-guided neural activity manipulation with a paramagnetic drug

Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed...

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Autores principales: Bricault, Sarah, Barandov, Ali, Harvey, Peter, DeTienne, Elizabeth, Hai, Aviad, Jasanoff, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952355/
https://www.ncbi.nlm.nih.gov/pubmed/31919353
http://dx.doi.org/10.1038/s41467-019-13933-5
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author Bricault, Sarah
Barandov, Ali
Harvey, Peter
DeTienne, Elizabeth
Hai, Aviad
Jasanoff, Alan
author_facet Bricault, Sarah
Barandov, Ali
Harvey, Peter
DeTienne, Elizabeth
Hai, Aviad
Jasanoff, Alan
author_sort Bricault, Sarah
collection PubMed
description Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.
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spelling pubmed-69523552020-01-13 Image-guided neural activity manipulation with a paramagnetic drug Bricault, Sarah Barandov, Ali Harvey, Peter DeTienne, Elizabeth Hai, Aviad Jasanoff, Alan Nat Commun Article Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity. Nature Publishing Group UK 2020-01-09 /pmc/articles/PMC6952355/ /pubmed/31919353 http://dx.doi.org/10.1038/s41467-019-13933-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Bricault, Sarah
Barandov, Ali
Harvey, Peter
DeTienne, Elizabeth
Hai, Aviad
Jasanoff, Alan
Image-guided neural activity manipulation with a paramagnetic drug
title Image-guided neural activity manipulation with a paramagnetic drug
title_full Image-guided neural activity manipulation with a paramagnetic drug
title_fullStr Image-guided neural activity manipulation with a paramagnetic drug
title_full_unstemmed Image-guided neural activity manipulation with a paramagnetic drug
title_short Image-guided neural activity manipulation with a paramagnetic drug
title_sort image-guided neural activity manipulation with a paramagnetic drug
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952355/
https://www.ncbi.nlm.nih.gov/pubmed/31919353
http://dx.doi.org/10.1038/s41467-019-13933-5
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