GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ

Signaling pathways controlling necrosis are still mysterious and debated. We applied a shRNA-based viability screen to identify critical elements of the necrotic response. We took advantage from a small molecule (G5) that makes covalent adducts with free thiols by Michael addition and elicits multip...

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Detalles Bibliográficos
Autores principales: Ciotti, Sonia, Iuliano, Luca, Cefalù, Sebastiano, Comelli, Marina, Mavelli, Irene, Di Giorgio, Eros, Brancolini, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952365/
https://www.ncbi.nlm.nih.gov/pubmed/31919413
http://dx.doi.org/10.1038/s41419-019-2202-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952365/
https://www.ncbi.nlm.nih.gov/pubmed/31919413
http://dx.doi.org/10.1038/s41419-019-2202-0

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