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GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ
Signaling pathways controlling necrosis are still mysterious and debated. We applied a shRNA-based viability screen to identify critical elements of the necrotic response. We took advantage from a small molecule (G5) that makes covalent adducts with free thiols by Michael addition and elicits multip...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952365/ https://www.ncbi.nlm.nih.gov/pubmed/31919413 http://dx.doi.org/10.1038/s41419-019-2202-0 |