Cargando…
Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor
Chiral recognition, such as enantioselective interactions of enzyme with chiral agents, is one of the most important issues in the natural world. But artificial chiral receptors are much less efficient than natural ones. For tackling the chiral recognition and enantiomer excess (ee) analysis, up unt...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952378/ https://www.ncbi.nlm.nih.gov/pubmed/31919426 http://dx.doi.org/10.1038/s41467-019-13955-z |
_version_ | 1783486436899553280 |
---|---|
author | Hu, Ming Yuan, Ying-Xue Wang, Weizhou Li, Dong-Mi Zhang, Hong-Chao Wu, Bai-Xing Liu, Minghua Zheng, Yan-Song |
author_facet | Hu, Ming Yuan, Ying-Xue Wang, Weizhou Li, Dong-Mi Zhang, Hong-Chao Wu, Bai-Xing Liu, Minghua Zheng, Yan-Song |
author_sort | Hu, Ming |
collection | PubMed |
description | Chiral recognition, such as enantioselective interactions of enzyme with chiral agents, is one of the most important issues in the natural world. But artificial chiral receptors are much less efficient than natural ones. For tackling the chiral recognition and enantiomer excess (ee) analysis, up until now all the fluorescent receptors have been developed based on fluorescence intensity changes. Here we report that the chiral recognition of a large number of chiral carboxylic acids, including chiral agrochemicals 2,4-D, is carried out based on fluorescent colour changes rather than intensity changes of AIEgen rotors. Moreover, the fluorescence wavelength of the AIEgen rotor linearly changes with ee of the carboxylic acid, enabling the ee to be accurately measured with average absolute errors (AAE) of less than 2.8%. Theoretical calculation demonstrates that the wavelength change is ascribed to the rotation of the AIEgen rotor upon interaction with different enantiomers. |
format | Online Article Text |
id | pubmed-6952378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69523782020-01-13 Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor Hu, Ming Yuan, Ying-Xue Wang, Weizhou Li, Dong-Mi Zhang, Hong-Chao Wu, Bai-Xing Liu, Minghua Zheng, Yan-Song Nat Commun Article Chiral recognition, such as enantioselective interactions of enzyme with chiral agents, is one of the most important issues in the natural world. But artificial chiral receptors are much less efficient than natural ones. For tackling the chiral recognition and enantiomer excess (ee) analysis, up until now all the fluorescent receptors have been developed based on fluorescence intensity changes. Here we report that the chiral recognition of a large number of chiral carboxylic acids, including chiral agrochemicals 2,4-D, is carried out based on fluorescent colour changes rather than intensity changes of AIEgen rotors. Moreover, the fluorescence wavelength of the AIEgen rotor linearly changes with ee of the carboxylic acid, enabling the ee to be accurately measured with average absolute errors (AAE) of less than 2.8%. Theoretical calculation demonstrates that the wavelength change is ascribed to the rotation of the AIEgen rotor upon interaction with different enantiomers. Nature Publishing Group UK 2020-01-09 /pmc/articles/PMC6952378/ /pubmed/31919426 http://dx.doi.org/10.1038/s41467-019-13955-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hu, Ming Yuan, Ying-Xue Wang, Weizhou Li, Dong-Mi Zhang, Hong-Chao Wu, Bai-Xing Liu, Minghua Zheng, Yan-Song Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor |
title | Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor |
title_full | Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor |
title_fullStr | Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor |
title_full_unstemmed | Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor |
title_short | Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor |
title_sort | chiral recognition and enantiomer excess determination based on emission wavelength change of aiegen rotor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952378/ https://www.ncbi.nlm.nih.gov/pubmed/31919426 http://dx.doi.org/10.1038/s41467-019-13955-z |
work_keys_str_mv | AT huming chiralrecognitionandenantiomerexcessdeterminationbasedonemissionwavelengthchangeofaiegenrotor AT yuanyingxue chiralrecognitionandenantiomerexcessdeterminationbasedonemissionwavelengthchangeofaiegenrotor AT wangweizhou chiralrecognitionandenantiomerexcessdeterminationbasedonemissionwavelengthchangeofaiegenrotor AT lidongmi chiralrecognitionandenantiomerexcessdeterminationbasedonemissionwavelengthchangeofaiegenrotor AT zhanghongchao chiralrecognitionandenantiomerexcessdeterminationbasedonemissionwavelengthchangeofaiegenrotor AT wubaixing chiralrecognitionandenantiomerexcessdeterminationbasedonemissionwavelengthchangeofaiegenrotor AT liuminghua chiralrecognitionandenantiomerexcessdeterminationbasedonemissionwavelengthchangeofaiegenrotor AT zhengyansong chiralrecognitionandenantiomerexcessdeterminationbasedonemissionwavelengthchangeofaiegenrotor |