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Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

Antimicrobial resistance is a major global threat that calls for new antibiotics. Globomycin and myxovirescin are two natural antibiotics that target the lipoprotein-processing enzyme, LspA, thereby compromising the integrity of the bacterial cell envelope. As part of a project aimed at understandin...

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Detalles Bibliográficos
Autores principales: Olatunji, Samir, Yu, Xiaoxiao, Bailey, Jonathan, Huang, Chia-Ying, Zapotoczna, Marta, Bowen, Katherine, Remškar, Maja, Müller, Rolf, Scanlan, Eoin M., Geoghegan, Joan A., Olieric, Vincent, Caffrey, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952399/
https://www.ncbi.nlm.nih.gov/pubmed/31919415
http://dx.doi.org/10.1038/s41467-019-13724-y