Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the bacterial type IV secretion system. Delivered CagA then undergoes tyrosine phosphorylation at the Glu-Pro-...

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Detalles Bibliográficos
Autores principales: Takahashi-Kanemitsu, Atsushi, Knight, Christopher T., Hatakeyama, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952403/
https://www.ncbi.nlm.nih.gov/pubmed/31804619
http://dx.doi.org/10.1038/s41423-019-0339-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952403/
https://www.ncbi.nlm.nih.gov/pubmed/31804619
http://dx.doi.org/10.1038/s41423-019-0339-5

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