The nuclear pore complex prevents sister chromatid recombination during replicative senescence

The Nuclear Pore Complex (NPC) has emerged as an important hub for processing various types of DNA damage. Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduces telomere relocalization to nuclear pores early after telomerase inactivation. This Nup1 modification als...

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Detalles Bibliográficos
Autores principales: Aguilera, Paula, Whalen, Jenna, Minguet, Christopher, Churikov, Dmitri, Freudenreich, Catherine, Simon, Marie-Noëlle, Géli, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952416/
https://www.ncbi.nlm.nih.gov/pubmed/31919430
http://dx.doi.org/10.1038/s41467-019-13979-5

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