Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells

Background: Mutations in genes encoding intercalated disk/desmosome proteins, such as plakophilin 2 (PKP2), cause arrhythmogenic cardiomyopathy (ACM). Desmosomes are responsible for myocyte–myocyte attachment and maintaining mechanical integrity of the myocardium. Methods: We knocked down Pkp2 in HL...

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Detalles Bibliográficos
Autores principales: Puzzi, Luca, Borin, Daniele, Gurha, Priyatansh, Lombardi, Raffaella, Martinelli, Valentina, Weiss, Marek, Andolfi, Laura, Lazzarino, Marco, Mestroni, Luisa, Marian, Ali J., Sbaizero, Orfeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952926/
https://www.ncbi.nlm.nih.gov/pubmed/31847412
http://dx.doi.org/10.3390/cells8121639

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