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Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate

Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and patholo...

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Autores principales: Tzeng, Hong-Tai, Chyuan, I-Tsu, Chen, Wei-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952933/
https://www.ncbi.nlm.nih.gov/pubmed/31847240
http://dx.doi.org/10.3390/cells8121633
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author Tzeng, Hong-Tai
Chyuan, I-Tsu
Chen, Wei-Yu
author_facet Tzeng, Hong-Tai
Chyuan, I-Tsu
Chen, Wei-Yu
author_sort Tzeng, Hong-Tai
collection PubMed
description Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. Lipid metabolites are emerging as the key players in the regulation of innate immune responses, and recent work has highlighted the importance of the lipid metabolite palmitate as an essential component in this regulation. Palmitate modulates innate immunity not only by regulating the activation of pattern recognition receptors in local innate immune cells, but also via coordinating immunological activity in inflammatory tissues. Moreover, protein palmitoylation controls various cellular physiological processes. Herein, we review the updated evidence that palmitate catabolism contributes to innate immune cell-mediated inflammatory processes that result in immunometabolic disorders.
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spelling pubmed-69529332020-01-23 Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate Tzeng, Hong-Tai Chyuan, I-Tsu Chen, Wei-Yu Cells Review Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. Lipid metabolites are emerging as the key players in the regulation of innate immune responses, and recent work has highlighted the importance of the lipid metabolite palmitate as an essential component in this regulation. Palmitate modulates innate immunity not only by regulating the activation of pattern recognition receptors in local innate immune cells, but also via coordinating immunological activity in inflammatory tissues. Moreover, protein palmitoylation controls various cellular physiological processes. Herein, we review the updated evidence that palmitate catabolism contributes to innate immune cell-mediated inflammatory processes that result in immunometabolic disorders. MDPI 2019-12-13 /pmc/articles/PMC6952933/ /pubmed/31847240 http://dx.doi.org/10.3390/cells8121633 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tzeng, Hong-Tai
Chyuan, I-Tsu
Chen, Wei-Yu
Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
title Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
title_full Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
title_fullStr Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
title_full_unstemmed Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
title_short Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
title_sort shaping of innate immune response by fatty acid metabolite palmitate
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952933/
https://www.ncbi.nlm.nih.gov/pubmed/31847240
http://dx.doi.org/10.3390/cells8121633
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