An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration

Alterations in the autophagosomal–lysosomal pathway are a major pathophysiological feature of CLN3 disease, which is the most common form of childhood-onset neurodegeneration. Accumulating autofluorescent lysosomal storage material in CLN3 disease, consisting of dolichols, lipids, biometals, and a p...

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Detalles Bibliográficos
Autores principales: Petcherski, Anton, Chandrachud, Uma, Butz, Elisabeth S., Klein, Madeleine C., Zhao, Wen-Ning, Reis, Surya A., Haggarty, Stephen J., Ruonala, Mika O., Cotman, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953052/
https://www.ncbi.nlm.nih.gov/pubmed/31783699
http://dx.doi.org/10.3390/cells8121531

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