Cargando…

An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight

Contrary to the widely held belief that mitochondrial ribosomes (mitoribosomes) are highly similar to bacterial ones, recent experimental evidence reveals that mitoribosomes do differ significantly from their bacterial counterparts. This review is focused on plant mitoribosomes, but we also highligh...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomal, Artur, Kwasniak-Owczarek, Malgorzata, Janska, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953067/
https://www.ncbi.nlm.nih.gov/pubmed/31816993
http://dx.doi.org/10.3390/cells8121562
_version_ 1783486565986598912
author Tomal, Artur
Kwasniak-Owczarek, Malgorzata
Janska, Hanna
author_facet Tomal, Artur
Kwasniak-Owczarek, Malgorzata
Janska, Hanna
author_sort Tomal, Artur
collection PubMed
description Contrary to the widely held belief that mitochondrial ribosomes (mitoribosomes) are highly similar to bacterial ones, recent experimental evidence reveals that mitoribosomes do differ significantly from their bacterial counterparts. This review is focused on plant mitoribosomes, but we also highlight the most striking similarities and differences between the plant and non-plant mitoribosomes. An analysis of the composition and structure of mitoribosomes in trypanosomes, yeast, mammals and plants uncovers numerous organism-specific features. For the plant mitoribosome, the most striking feature is the enormous size of the small subunit compared to the large one. Apart from the new structural information, possible functional peculiarities of different types of mitoribosomes are also discussed. Studies suggest that the protein composition of mitoribosomes is dynamic, especially during development, giving rise to a heterogeneous populations of ribosomes fulfilling specific functions. Moreover, convincing data shows that mitoribosomes interact with components involved in diverse mitochondrial gene expression steps, forming large expressosome-like structures.
format Online
Article
Text
id pubmed-6953067
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69530672020-01-23 An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight Tomal, Artur Kwasniak-Owczarek, Malgorzata Janska, Hanna Cells Review Contrary to the widely held belief that mitochondrial ribosomes (mitoribosomes) are highly similar to bacterial ones, recent experimental evidence reveals that mitoribosomes do differ significantly from their bacterial counterparts. This review is focused on plant mitoribosomes, but we also highlight the most striking similarities and differences between the plant and non-plant mitoribosomes. An analysis of the composition and structure of mitoribosomes in trypanosomes, yeast, mammals and plants uncovers numerous organism-specific features. For the plant mitoribosome, the most striking feature is the enormous size of the small subunit compared to the large one. Apart from the new structural information, possible functional peculiarities of different types of mitoribosomes are also discussed. Studies suggest that the protein composition of mitoribosomes is dynamic, especially during development, giving rise to a heterogeneous populations of ribosomes fulfilling specific functions. Moreover, convincing data shows that mitoribosomes interact with components involved in diverse mitochondrial gene expression steps, forming large expressosome-like structures. MDPI 2019-12-03 /pmc/articles/PMC6953067/ /pubmed/31816993 http://dx.doi.org/10.3390/cells8121562 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tomal, Artur
Kwasniak-Owczarek, Malgorzata
Janska, Hanna
An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight
title An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight
title_full An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight
title_fullStr An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight
title_full_unstemmed An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight
title_short An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight
title_sort update on mitochondrial ribosome biology: the plant mitoribosome in the spotlight
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953067/
https://www.ncbi.nlm.nih.gov/pubmed/31816993
http://dx.doi.org/10.3390/cells8121562
work_keys_str_mv AT tomalartur anupdateonmitochondrialribosomebiologytheplantmitoribosomeinthespotlight
AT kwasniakowczarekmalgorzata anupdateonmitochondrialribosomebiologytheplantmitoribosomeinthespotlight
AT janskahanna anupdateonmitochondrialribosomebiologytheplantmitoribosomeinthespotlight
AT tomalartur updateonmitochondrialribosomebiologytheplantmitoribosomeinthespotlight
AT kwasniakowczarekmalgorzata updateonmitochondrialribosomebiologytheplantmitoribosomeinthespotlight
AT janskahanna updateonmitochondrialribosomebiologytheplantmitoribosomeinthespotlight