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Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential

Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological s...

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Autores principales: Marina, Digregorio, Arnaud, Lombard, Paul Noel, Lumapat, Felix, Scholtes, Bernard, Rogister, Natacha, Coppieters
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953081/
https://www.ncbi.nlm.nih.gov/pubmed/31795417
http://dx.doi.org/10.3390/cells8121542
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author Marina, Digregorio
Arnaud, Lombard
Paul Noel, Lumapat
Felix, Scholtes
Bernard, Rogister
Natacha, Coppieters
author_facet Marina, Digregorio
Arnaud, Lombard
Paul Noel, Lumapat
Felix, Scholtes
Bernard, Rogister
Natacha, Coppieters
author_sort Marina, Digregorio
collection PubMed
description Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological stress. This phenomenon has been described in several cancers including in gliomas. Abnormal regulation of translation has encouraged the development of new therapeutics targeting the protein synthesis pathway. This approach could be meaningful for glioma given the fact that the median survival following diagnosis of the highest grade of glioma remains short despite current therapy. The identification of new targets for the development of novel therapeutics is therefore needed in order to improve this devastating overall survival rate. This review discusses current literature on translation in gliomas with a focus on the initiation step covering both the cap-dependent and cap-independent modes of initiation. The different translation initiation protagonists will be described in normal conditions and then in gliomas. In addition, their gene expression in gliomas will systematically be examined using two freely available datasets. Finally, we will discuss different pathways regulating translation initiation and current drugs targeting the translational machinery and their potential for the treatment of gliomas.
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spelling pubmed-69530812020-01-23 Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential Marina, Digregorio Arnaud, Lombard Paul Noel, Lumapat Felix, Scholtes Bernard, Rogister Natacha, Coppieters Cells Review Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological stress. This phenomenon has been described in several cancers including in gliomas. Abnormal regulation of translation has encouraged the development of new therapeutics targeting the protein synthesis pathway. This approach could be meaningful for glioma given the fact that the median survival following diagnosis of the highest grade of glioma remains short despite current therapy. The identification of new targets for the development of novel therapeutics is therefore needed in order to improve this devastating overall survival rate. This review discusses current literature on translation in gliomas with a focus on the initiation step covering both the cap-dependent and cap-independent modes of initiation. The different translation initiation protagonists will be described in normal conditions and then in gliomas. In addition, their gene expression in gliomas will systematically be examined using two freely available datasets. Finally, we will discuss different pathways regulating translation initiation and current drugs targeting the translational machinery and their potential for the treatment of gliomas. MDPI 2019-11-29 /pmc/articles/PMC6953081/ /pubmed/31795417 http://dx.doi.org/10.3390/cells8121542 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marina, Digregorio
Arnaud, Lombard
Paul Noel, Lumapat
Felix, Scholtes
Bernard, Rogister
Natacha, Coppieters
Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential
title Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential
title_full Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential
title_fullStr Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential
title_full_unstemmed Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential
title_short Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential
title_sort relevance of translation initiation in diffuse glioma biology and its therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953081/
https://www.ncbi.nlm.nih.gov/pubmed/31795417
http://dx.doi.org/10.3390/cells8121542
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