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Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential
Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953081/ https://www.ncbi.nlm.nih.gov/pubmed/31795417 http://dx.doi.org/10.3390/cells8121542 |
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author | Marina, Digregorio Arnaud, Lombard Paul Noel, Lumapat Felix, Scholtes Bernard, Rogister Natacha, Coppieters |
author_facet | Marina, Digregorio Arnaud, Lombard Paul Noel, Lumapat Felix, Scholtes Bernard, Rogister Natacha, Coppieters |
author_sort | Marina, Digregorio |
collection | PubMed |
description | Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological stress. This phenomenon has been described in several cancers including in gliomas. Abnormal regulation of translation has encouraged the development of new therapeutics targeting the protein synthesis pathway. This approach could be meaningful for glioma given the fact that the median survival following diagnosis of the highest grade of glioma remains short despite current therapy. The identification of new targets for the development of novel therapeutics is therefore needed in order to improve this devastating overall survival rate. This review discusses current literature on translation in gliomas with a focus on the initiation step covering both the cap-dependent and cap-independent modes of initiation. The different translation initiation protagonists will be described in normal conditions and then in gliomas. In addition, their gene expression in gliomas will systematically be examined using two freely available datasets. Finally, we will discuss different pathways regulating translation initiation and current drugs targeting the translational machinery and their potential for the treatment of gliomas. |
format | Online Article Text |
id | pubmed-6953081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69530812020-01-23 Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential Marina, Digregorio Arnaud, Lombard Paul Noel, Lumapat Felix, Scholtes Bernard, Rogister Natacha, Coppieters Cells Review Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological stress. This phenomenon has been described in several cancers including in gliomas. Abnormal regulation of translation has encouraged the development of new therapeutics targeting the protein synthesis pathway. This approach could be meaningful for glioma given the fact that the median survival following diagnosis of the highest grade of glioma remains short despite current therapy. The identification of new targets for the development of novel therapeutics is therefore needed in order to improve this devastating overall survival rate. This review discusses current literature on translation in gliomas with a focus on the initiation step covering both the cap-dependent and cap-independent modes of initiation. The different translation initiation protagonists will be described in normal conditions and then in gliomas. In addition, their gene expression in gliomas will systematically be examined using two freely available datasets. Finally, we will discuss different pathways regulating translation initiation and current drugs targeting the translational machinery and their potential for the treatment of gliomas. MDPI 2019-11-29 /pmc/articles/PMC6953081/ /pubmed/31795417 http://dx.doi.org/10.3390/cells8121542 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marina, Digregorio Arnaud, Lombard Paul Noel, Lumapat Felix, Scholtes Bernard, Rogister Natacha, Coppieters Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential |
title | Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential |
title_full | Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential |
title_fullStr | Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential |
title_full_unstemmed | Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential |
title_short | Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential |
title_sort | relevance of translation initiation in diffuse glioma biology and its therapeutic potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953081/ https://www.ncbi.nlm.nih.gov/pubmed/31795417 http://dx.doi.org/10.3390/cells8121542 |
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