The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium

Post-transcriptional regulation plays a key role in modulating gene expression, and the perturbation of transcriptomic equilibrium has been shown to drive the development of multiple diseases including cancer. Recent studies have revealed the existence of multiple post-transcriptional processes that...

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Detalles Bibliográficos
Autores principales: Desi, Ng, Tay, Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953095/
https://www.ncbi.nlm.nih.gov/pubmed/31847302
http://dx.doi.org/10.3390/cells8121634
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author Desi, Ng
Tay, Yvonne
author_facet Desi, Ng
Tay, Yvonne
author_sort Desi, Ng
collection PubMed
description Post-transcriptional regulation plays a key role in modulating gene expression, and the perturbation of transcriptomic equilibrium has been shown to drive the development of multiple diseases including cancer. Recent studies have revealed the existence of multiple post-transcriptional processes that coordinatively regulate the expression and function of each RNA transcript. In this review, we summarize the latest research describing various mechanisms by which small alterations in RNA processing or function can potentially reshape the transcriptomic landscape, and the impact that this may have on cancer development.
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spelling pubmed-69530952020-01-23 The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium Desi, Ng Tay, Yvonne Cells Review Post-transcriptional regulation plays a key role in modulating gene expression, and the perturbation of transcriptomic equilibrium has been shown to drive the development of multiple diseases including cancer. Recent studies have revealed the existence of multiple post-transcriptional processes that coordinatively regulate the expression and function of each RNA transcript. In this review, we summarize the latest research describing various mechanisms by which small alterations in RNA processing or function can potentially reshape the transcriptomic landscape, and the impact that this may have on cancer development. MDPI 2019-12-13 /pmc/articles/PMC6953095/ /pubmed/31847302 http://dx.doi.org/10.3390/cells8121634 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Desi, Ng
Tay, Yvonne
The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium
title The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium
title_full The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium
title_fullStr The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium
title_full_unstemmed The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium
title_short The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium
title_sort butterfly effect of rna alterations on transcriptomic equilibrium
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953095/
https://www.ncbi.nlm.nih.gov/pubmed/31847302
http://dx.doi.org/10.3390/cells8121634
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