Cargando…

Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study

The HIV accessory protein Nef downregulates the viral entry receptor CD4, the Human Leukocyte Antigen (HLA)-A and -B molecules, the Serine incorporator 5 (SERINC5) protein and other molecules from the infected cell surface, thereby promoting viral infectivity, replication and immune evasion. The nef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sudderuddin, Hanwei, Kinloch, Natalie N., Jin, Steven W., Miller, Rachel L., Jones, Bradley R., Brumme, Chanson J., Joy, Jeffrey B., Brockman, Mark A., Brumme, Zabrina L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953280/ https://www.ncbi.nlm.nih.gov/pubmed/31918727 http://dx.doi.org/10.1186/s12977-019-0510-1

Ejemplares similares

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5
por: Jin, Steven W., et al.
Publicado: (2020)

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity
por: Jin, Steven W., et al.
Publicado: (2019)

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
por: Naicker, Delon, et al.
Publicado: (2023)

Naturally-arising amino acid polymorphisms of HIV-1 Nef that differentially modulate downregulation of HLA-A and HLA-B molecules
por: Mahiti, Macdonald, et al.
Publicado: (2013)

Proviral Turnover During Untreated HIV Infection Is Dynamic and Variable Between Hosts, Impacting Reservoir Composition on ART
por: Brooks, Kelsie, et al.
Publicado: (2021)

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences
por: Mahiti, Macdonald, et al.
Publicado: (2016)

HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy
por: Omondi, F. Harrison, et al.
Publicado: (2021)

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes
por: Mann, Jaclyn K, et al.
Publicado: (2013)

HIV reservoirs are dominated by genetically younger and clonally enriched proviruses
por: Kinloch, Natalie N., et al.
Publicado: (2023)

SARS-CoV-2 RNA Quantification Using Droplet Digital RT-PCR
por: Kinloch, Natalie N., et al.
Publicado: (2021)

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins
por: Brumme, Zabrina L., et al.
Publicado: (2009)

Phylogenetic approach to recover integration dates of latent HIV sequences within-host
por: Jones, Bradley R., et al.
Publicado: (2018)

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
por: Usami, Yoshiko, et al.
Publicado: (2015)

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5
por: Wu, Yuanfei, et al.
Publicado: (2019)

Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors
por: Umviligihozo, Gisele, et al.
Publicado: (2022)

High Levels of Dual-Class Drug Resistance in HIV-Infected Children Failing First-Line Antiretroviral Therapy in Southern Ethiopia
por: Tadesse, Birkneh Tilahun, et al.
Publicado: (2018)

Impairment of viral replication capacity by nef alleles from HIV elite controllers
por: Mwimanzi, Philip, et al.
Publicado: (2011)

HLA-C downregulation by HIV-1 adapts to host HLA genotype
por: Bachtel, Nathaniel D., et al.
Publicado: (2018)

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor
por: Fackler, Oliver T.
Publicado: (2015)

Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico
por: Soto-Nava, Maribel, et al.
Publicado: (2018)

Attenuation of multiple Nef functions in HIV-1 elite controllers
por: Mwimanzi, Philip, et al.
Publicado: (2013)

Viral adaptation to immune selection pressure by HLA class I–restricted CTL responses targeting epitopes in HIV frameshift sequences
por: Berger, Christoph T., et al.
Publicado: (2010)

Concordance of HIV transmission risk factors elucidated using viral diversification rate and phylogenetic clustering
por: McLaughlin, Angela, et al.
Publicado: (2021)

Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs
por: Brockman, Mark A., et al.
Publicado: (2015)

Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals
por: Sakai, Keiko, et al.
Publicado: (2015)

Erratum to: Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals
por: Sakai, Keiko, et al.
Publicado: (2015)

Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction
por: Kruize, Zita, et al.
Publicado: (2021)

Proteasomal degradation of human SERINC4: A potent host anti-HIV-1 factor that is antagonized by nef
por: Qiu, Xusheng, et al.
Publicado: (2020)

Extensive host immune adaptation in a concentrated North American HIV epidemic
por: Brumme, Zabrina L., et al.
Publicado: (2018)

Detection of HIV transmission hotspots in British Columbia, Canada: A novel framework for the prioritization and allocation of treatment and prevention resources
por: McLaughlin, Angela, et al.
Publicado: (2019)

HIV proviral genetic diversity, compartmentalization and inferred dynamics in lung and blood during long-term suppressive antiretroviral therapy
por: Shahid, Aniqa, et al.
Publicado: (2022)

Evaluation of Nasopharyngeal Swab Collection Techniques for Nucleic Acid Recovery and Participant Experience: Recommendations for COVID-19 Diagnostics
por: Kinloch, Natalie N, et al.
Publicado: (2020)

Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells
por: Ramirez, Peter W., et al.
Publicado: (2023)

P09-10. Impact of CTL escape mutations in HIV-1 Nef on viral replication
por: Oniangue-Ndza, C, et al.
Publicado: (2009)

Sociodemographic correlates of HIV drug resistance and access to drug resistance testing in British Columbia, Canada
por: Rocheleau, Genevieve, et al.
Publicado: (2017)

A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation
por: Firrito, Claudia, et al.
Publicado: (2023)

Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals
por: Toyoda, Mako, et al.
Publicado: (2020)

Statistical Resolution of Ambiguous HLA Typing Data
por: Listgarten, Jennifer, et al.
Publicado: (2008)

Rates and Correlates of Short Term Virologic Response among Treatment-Naïve HIV-Infected Children Initiating Antiretroviral Therapy in Ethiopia: A Multi-Center Prospective Cohort Study
por: Tadesse, Birkneh Tilahun, et al.
Publicado: (2019)

AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4
por: Olety, Balaji, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7cn4knidqomfhjnf1tsr7e8t6t