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Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis

BACKGROUND: Depression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB treatment. METHODS: We...

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Autores principales: Ruiz-Grosso, Paulo, Cachay, Rodrigo, de la Flor, Adriana, Schwalb, Alvaro, Ugarte-Gil, Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953784/
https://www.ncbi.nlm.nih.gov/pubmed/31923280
http://dx.doi.org/10.1371/journal.pone.0227472
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author Ruiz-Grosso, Paulo
Cachay, Rodrigo
de la Flor, Adriana
Schwalb, Alvaro
Ugarte-Gil, Cesar
author_facet Ruiz-Grosso, Paulo
Cachay, Rodrigo
de la Flor, Adriana
Schwalb, Alvaro
Ugarte-Gil, Cesar
author_sort Ruiz-Grosso, Paulo
collection PubMed
description BACKGROUND: Depression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB treatment. METHODS: We systematically reviewed studies that evaluated depressive symptoms (DS) directly or indirectly through psychological distress (PD) and measured negative treatment outcomes of drug-sensitive pulmonary TB, defined as death, loss to follow-up, or non-adherence. Sources included PubMed, Global Health Library, Embase, Scopus and Web of Science from inception to August 2019. RESULTS: Of the 2,970 studies initially identified, eight articles were eligible for inclusion and two were used for the primary outcome meta-analysis. We found a strong association between DS and negative TB treatment outcomes (OR = 4.26; CI95%:2.33–7.79; I(2) = 0%). DS were also associated with loss to follow-up (OR = 8.70; CI95%:6.50–11.64; I(2) = 0%) and death (OR = 2.85; CI95%:1.52–5.36; I(2) = 0%). Non-adherence was not associated with DS and PD (OR = 1.34; CI95%:0.70–2.72; I(2) = 94.36) or PD alone (OR = 0.92; CI95%:0.81–1.05; I(2) = 0%). CONCLUSIONS: DS are associated with the negative TB treatment outcomes of death and loss to follow-up. Considerable heterogeneity exists in the definition of depression and outcomes such as non-adherence across the limited number of studies on this topic.
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spelling pubmed-69537842020-01-21 Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis Ruiz-Grosso, Paulo Cachay, Rodrigo de la Flor, Adriana Schwalb, Alvaro Ugarte-Gil, Cesar PLoS One Research Article BACKGROUND: Depression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB treatment. METHODS: We systematically reviewed studies that evaluated depressive symptoms (DS) directly or indirectly through psychological distress (PD) and measured negative treatment outcomes of drug-sensitive pulmonary TB, defined as death, loss to follow-up, or non-adherence. Sources included PubMed, Global Health Library, Embase, Scopus and Web of Science from inception to August 2019. RESULTS: Of the 2,970 studies initially identified, eight articles were eligible for inclusion and two were used for the primary outcome meta-analysis. We found a strong association between DS and negative TB treatment outcomes (OR = 4.26; CI95%:2.33–7.79; I(2) = 0%). DS were also associated with loss to follow-up (OR = 8.70; CI95%:6.50–11.64; I(2) = 0%) and death (OR = 2.85; CI95%:1.52–5.36; I(2) = 0%). Non-adherence was not associated with DS and PD (OR = 1.34; CI95%:0.70–2.72; I(2) = 94.36) or PD alone (OR = 0.92; CI95%:0.81–1.05; I(2) = 0%). CONCLUSIONS: DS are associated with the negative TB treatment outcomes of death and loss to follow-up. Considerable heterogeneity exists in the definition of depression and outcomes such as non-adherence across the limited number of studies on this topic. Public Library of Science 2020-01-10 /pmc/articles/PMC6953784/ /pubmed/31923280 http://dx.doi.org/10.1371/journal.pone.0227472 Text en © 2020 Ruiz-Grosso et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ruiz-Grosso, Paulo
Cachay, Rodrigo
de la Flor, Adriana
Schwalb, Alvaro
Ugarte-Gil, Cesar
Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
title Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
title_full Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
title_fullStr Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
title_full_unstemmed Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
title_short Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
title_sort association between tuberculosis and depression on negative outcomes of tuberculosis treatment: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953784/
https://www.ncbi.nlm.nih.gov/pubmed/31923280
http://dx.doi.org/10.1371/journal.pone.0227472
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