Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of BECN1 at the genetic level is complicated due to its genomic proximity to BRCA1 on...

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Detalles Bibliográficos
Autores principales: Delaney, Joe R., Patel, Chandni B., Bapat, Jaidev, Jones, Christian M., Ramos-Zapatero, Maria, Ortell, Katherine K., Tanios, Ralph, Haghighiabyaneh, Mina, Axelrod, Joshua, DeStefano, John W., Tancioni, Isabelle, Schlaepfer, David D., Harismendy, Olivier, La Spada, Albert R., Stupack, Dwayne G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953790/
https://www.ncbi.nlm.nih.gov/pubmed/31923184
http://dx.doi.org/10.1371/journal.pgen.1008558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953790/
https://www.ncbi.nlm.nih.gov/pubmed/31923184
http://dx.doi.org/10.1371/journal.pgen.1008558

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