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Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs
Topoisomerases are well-validated targets for cancer chemotherapy and DNA topoisomerase 1 (Top1) is the sole target of the camptothecin (CPT) class of anticancer drugs. Over the last 20 years, multiple studies have shown Top1 activity is modulated by non-native DNA structures and this can lead to tr...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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OAE Publishing Inc.
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953902/ https://www.ncbi.nlm.nih.gov/pubmed/31930190 http://dx.doi.org/10.20517/cdr.2019.95 |