Cargando…

Common activation mechanism of class A GPCRs

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology. Understanding receptor activation mechanism is critical for discovering novel therapeutics since about one-third of all marketed drugs target members of this family. GPCR activation is an allosteric pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Qingtong, Yang, Dehua, Wu, Meng, Guo, Yu, Guo, Wanjing, Zhong, Li, Cai, Xiaoqing, Dai, Antao, Jang, Wonjo, Shakhnovich, Eugene I, Liu, Zhi-Jie, Stevens, Raymond C, Lambert, Nevin A, Babu, M Madan, Wang, Ming-Wei, Zhao, Suwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954041/ https://www.ncbi.nlm.nih.gov/pubmed/31855179 http://dx.doi.org/10.7554/eLife.50279

Ejemplares similares

Constitutive G protein coupling profiles of understudied orphan GPCRs
por: Lu, Sumin, et al.
Publicado: (2021)

Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening
por: Zhou, Qingtong, et al.
Publicado: (2021)

Dynamic metastable long-living droplets formed by sticker-spacer proteins
por: Ranganathan, Srivastav, et al.
Publicado: (2020)

Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak
por: Rodrigues, João V, et al.
Publicado: (2019)

Identification of a carbohydrate recognition motif of purinergic receptors
por: Zhao, Lifen, et al.
Publicado: (2023)

Allosteric Modulation of GPCRs of Class A by Cholesterol
por: Jakubík, Jan, et al.
Publicado: (2021)

Activation and Speciation Mechanisms in Class A GPCRs
por: Wingert, Bentley, et al.
Publicado: (2022)

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs
por: Harpsøe, Kasper, et al.
Publicado: (2017)

Development of antibacterial compounds that constrain evolutionary pathways to resistance
por: Zhang, Yanmin, et al.
Publicado: (2021)

The role of Cysteine 6.47 in class A GPCRs
por: Olivella, Mireia, et al.
Publicado: (2013)

Cholesterol in Class C GPCRs: Role, Relevance, and Localization
por: Isu, Ugochi H., et al.
Publicado: (2023)

The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs
por: Egyed, Attila, et al.
Publicado: (2022)

New Insights into the Structure and Function of Class B1 GPCRs
por: Cary, Brian P, et al.
Publicado: (2022)

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells
por: Wan, Qingwen, et al.
Publicado: (2018)

Unifying view of mechanical and functional hotspots across class A GPCRs
por: Ponzoni, Luca, et al.
Publicado: (2017)

Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs
por: Burggraaff, Lindsey, et al.
Publicado: (2020)

Distinct classes of potassium channels fused to GPCRs as electrical signaling biosensors
por: García-Fernández, M. Dolores, et al.
Publicado: (2021)

Residue 6.43 defines receptor function in class F GPCRs
por: Turku, Ainoleena, et al.
Publicado: (2021)

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening
por: Qin, Shanshan, et al.
Publicado: (2018)

An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling
por: Jang, Wonjo, et al.
Publicado: (2020)

Receptor oligomerization: from early evidence to current understanding in class B GPCRs
por: Ng, Stephanie Y. L., et al.
Publicado: (2013)

Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism
por: Dalton, James AR, et al.
Publicado: (2015)

The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
por: Boczek, Tomasz, et al.
Publicado: (2021)

Illuminating the life of GPCRs
por: Böhme, Ilka, et al.
Publicado: (2009)

The folding interactome of GPCRs
por: Bergmayr, Christian, et al.
Publicado: (2011)

Neuropeptide GPCRs in Neuroendocrinology
por: Vaudry, Hubert, et al.
Publicado: (2014)

Editorial: GPCRs and Cancer
por: Chen, Suzie
Publicado: (2017)

Drug-induced diabetes type 2: In silico study involving class B GPCRs
por: Latek, Dorota, et al.
Publicado: (2019)

The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi
por: Krishnan, Arunkumar, et al.
Publicado: (2012)

An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRs
por: Lundstrom, Kenneth
Publicado: (2009)

Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma
por: Raymond, Jérémy H., et al.
Publicado: (2022)

Common Docker images and Gitlab runners for FPGA development
por: Byszuk, Adrian
Publicado: (2022)

Nematode and Arthropod Genomes Provide New Insights into the Evolution of Class 2 B1 GPCRs
por: Cardoso, João C. R., et al.
Publicado: (2014)

The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation
por: Winfield, Ian, et al.
Publicado: (2022)

TRPCs, GPCRs and the Bayliss effect
por: Voets, Thomas, et al.
Publicado: (2009)

Neuropeptide GPCRs in C. elegans
por: Frooninckx, Lotte, et al.
Publicado: (2012)

GPCRs in Autocrine and Paracrine Regulations
por: Tse, Lap Hang, et al.
Publicado: (2019)

Revisiting the classification of adhesion GPCRs
por: Scholz, Nicole, et al.
Publicado: (2019)

Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics
por: Brassington, Kurt, et al.
Publicado: (2022)

Structural analysis of the dual agonism at GLP-1R and GCGR
por: Li, Yang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1g8nr46nu34lgc47f8i49mk089