Cas9 Mediated Correction of β-catenin Mutation and Restoring the Expression of Protein Phosphorylation in Colon Cancer HCT-116 Cells Decrease Cell Proliferation in vitro and Hamper Tumor Growth in Mice in vivo

PURPOSE: Colorectal cancer (CRC) is one of the major contributors to cancer mortality and morbidity. Finding strategies to fight against CRC is urgently required. Mutations in driver genes of  APC or β-catenin play an important role in the occurrence and progression of CRC. In the present study, we...

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Detalles Bibliográficos
Autores principales: Li, Yanlan, Li, Xiangning, Qu, Jiayao, Luo, Dixian, Hu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954092/
https://www.ncbi.nlm.nih.gov/pubmed/32021251
http://dx.doi.org/10.2147/OTT.S225556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954092/
https://www.ncbi.nlm.nih.gov/pubmed/32021251
http://dx.doi.org/10.2147/OTT.S225556

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