The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma

Sonic Hedgehog (SHH) medulloblastomas are brain tumours that arise in the posterior fossa. Cancer-propagating cells (CPCs) provide a reservoir of cells capable of tumour regeneration and relapse post-treatment. Understanding and targeting the mechanisms by which CPCs are maintained and expanded in S...

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Detalles Bibliográficos
Autores principales: Sarić, Nemanja, Selby, Matthew, Ramaswamy, Vijay, Kool, Marcel, Stockinger, Brigitta, Hogstrand, Christer, Williamson, Daniel, Marino, Silvia, Taylor, Michael D., Clifford, Steven C., Basson, M. Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954114/
https://www.ncbi.nlm.nih.gov/pubmed/31924815
http://dx.doi.org/10.1038/s41598-019-56876-z

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