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Sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis

Neuromodulation based on the vagal anti‐inflammatory reflex has emerged as an exciting therapeutic approach for chronic inflammatory diseases. However, it is unclear whether direct stimulation of the vagus or of pelvic nerves coming from sacral roots, providing the bulk of colonic parasympathetic in...

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Autores principales: Pasricha, Trisha S., Zhang, Han, Zhang, Nina, Chen, Jiande D. Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954119/
https://www.ncbi.nlm.nih.gov/pubmed/31925899
http://dx.doi.org/10.14814/phy2.14294
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author Pasricha, Trisha S.
Zhang, Han
Zhang, Nina
Chen, Jiande D. Z.
author_facet Pasricha, Trisha S.
Zhang, Han
Zhang, Nina
Chen, Jiande D. Z.
author_sort Pasricha, Trisha S.
collection PubMed
description Neuromodulation based on the vagal anti‐inflammatory reflex has emerged as an exciting therapeutic approach for chronic inflammatory diseases. However, it is unclear whether direct stimulation of the vagus or of pelvic nerves coming from sacral roots, providing the bulk of colonic parasympathetic innervation, is the best approach. We hypothesized that sacral nerve stimulation (SNS) would be an effective treatment for colitis. Age and sex‐matched Sprague‐Dawley rats were administered 5% dextran sulphate sodium (DSS) in drinking water ad libitum for 7 days. A group of rats was sacrificed after DSS treatment, and the remaining rats were randomized to either sham‐SNS or SNS groups, which were performed for 1 hr daily for 10 days. Stimulations were delivered via chronically implanted electrodes using an 8‐channel universal pulse generator. Sacral nerve stimulation promoted recovery of colitis demonstrated by decreased disease activity index, myeloperoxidase activity, tissue TNF‐alpha, and histological scores as well as an increased colonic M2 macrophage population. Heart rate variability analysis demonstrated a decrease in low frequency and increase in high frequency with SNS, corresponding to increased vagal tone. Additionally, plasma pancreatic peptide was increased and norepinephrine was decreased after SNS in colitis while colon tissue acetylcholine was increased with SNS. This is the first study to the best of our knowledge that demonstrates the benefit of SNS with autonomic mediation. SNS alters the expression of inflammatory cytokines and macrophages as well as modulates neurotransmitters involved in systemic inflammation.
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spelling pubmed-69541192020-01-14 Sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis Pasricha, Trisha S. Zhang, Han Zhang, Nina Chen, Jiande D. Z. Physiol Rep Original Research Neuromodulation based on the vagal anti‐inflammatory reflex has emerged as an exciting therapeutic approach for chronic inflammatory diseases. However, it is unclear whether direct stimulation of the vagus or of pelvic nerves coming from sacral roots, providing the bulk of colonic parasympathetic innervation, is the best approach. We hypothesized that sacral nerve stimulation (SNS) would be an effective treatment for colitis. Age and sex‐matched Sprague‐Dawley rats were administered 5% dextran sulphate sodium (DSS) in drinking water ad libitum for 7 days. A group of rats was sacrificed after DSS treatment, and the remaining rats were randomized to either sham‐SNS or SNS groups, which were performed for 1 hr daily for 10 days. Stimulations were delivered via chronically implanted electrodes using an 8‐channel universal pulse generator. Sacral nerve stimulation promoted recovery of colitis demonstrated by decreased disease activity index, myeloperoxidase activity, tissue TNF‐alpha, and histological scores as well as an increased colonic M2 macrophage population. Heart rate variability analysis demonstrated a decrease in low frequency and increase in high frequency with SNS, corresponding to increased vagal tone. Additionally, plasma pancreatic peptide was increased and norepinephrine was decreased after SNS in colitis while colon tissue acetylcholine was increased with SNS. This is the first study to the best of our knowledge that demonstrates the benefit of SNS with autonomic mediation. SNS alters the expression of inflammatory cytokines and macrophages as well as modulates neurotransmitters involved in systemic inflammation. John Wiley and Sons Inc. 2020-01-10 /pmc/articles/PMC6954119/ /pubmed/31925899 http://dx.doi.org/10.14814/phy2.14294 Text en © 2020 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Pasricha, Trisha S.
Zhang, Han
Zhang, Nina
Chen, Jiande D. Z.
Sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis
title Sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis
title_full Sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis
title_fullStr Sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis
title_full_unstemmed Sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis
title_short Sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis
title_sort sacral nerve stimulation prompts vagally‐mediated amelioration of rodent colitis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954119/
https://www.ncbi.nlm.nih.gov/pubmed/31925899
http://dx.doi.org/10.14814/phy2.14294
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