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Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review

PURPOSE: A growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summa...

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Autores principales: Verhaak, Eline, Gehring, Karin, Hanssens, Patrick E. J., Aaronson, Neil K., Sitskoorn, Margriet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954134/
https://www.ncbi.nlm.nih.gov/pubmed/31792879
http://dx.doi.org/10.1007/s00520-019-05136-x
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author Verhaak, Eline
Gehring, Karin
Hanssens, Patrick E. J.
Aaronson, Neil K.
Sitskoorn, Margriet M.
author_facet Verhaak, Eline
Gehring, Karin
Hanssens, Patrick E. J.
Aaronson, Neil K.
Sitskoorn, Margriet M.
author_sort Verhaak, Eline
collection PubMed
description PURPOSE: A growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summarizes the current knowledge about the HRQoL of patients with BM after SRS. METHODS: We searched EMBASE, Medline Ovid, Web-of-Science, the Cochrane Database, PsycINFO Ovid, and Google Scholar up to November 15, 2018. Studies in patients with BM in which HRQoL was assessed before and after SRS and analyzed over time were included. Studies including populations of several types of brain cancer and/or several types of treatments were included if the results for patients with BM and treatment with SRS alone were described separately. RESULTS: Out of 3638 published articles, 9 studies met the eligibility criteria and were included. In 4 out of 7 studies on group results, overall HRQoL of patients with BM remained stable after SRS. In small study samples of longer-term survivors, overall HRQoL remained stable up to 12 months post-SRS. Contradictory results were reported for physical and general/global HRQoL, which might be explained by the different questionnaires that were used. CONCLUSIONS: In general, SRS does not have significant negative effects on patients’ overall HRQoL over time. Future research is needed to analyze different aspects of HRQoL, differences in individual changes in HRQoL after SRS, and factors that influence these changes. These studies should take into account several methodological issues as discussed in this review. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00520-019-05136-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-69541342020-01-23 Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review Verhaak, Eline Gehring, Karin Hanssens, Patrick E. J. Aaronson, Neil K. Sitskoorn, Margriet M. Support Care Cancer Review Article PURPOSE: A growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summarizes the current knowledge about the HRQoL of patients with BM after SRS. METHODS: We searched EMBASE, Medline Ovid, Web-of-Science, the Cochrane Database, PsycINFO Ovid, and Google Scholar up to November 15, 2018. Studies in patients with BM in which HRQoL was assessed before and after SRS and analyzed over time were included. Studies including populations of several types of brain cancer and/or several types of treatments were included if the results for patients with BM and treatment with SRS alone were described separately. RESULTS: Out of 3638 published articles, 9 studies met the eligibility criteria and were included. In 4 out of 7 studies on group results, overall HRQoL of patients with BM remained stable after SRS. In small study samples of longer-term survivors, overall HRQoL remained stable up to 12 months post-SRS. Contradictory results were reported for physical and general/global HRQoL, which might be explained by the different questionnaires that were used. CONCLUSIONS: In general, SRS does not have significant negative effects on patients’ overall HRQoL over time. Future research is needed to analyze different aspects of HRQoL, differences in individual changes in HRQoL after SRS, and factors that influence these changes. These studies should take into account several methodological issues as discussed in this review. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00520-019-05136-x) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-12-02 2020 /pmc/articles/PMC6954134/ /pubmed/31792879 http://dx.doi.org/10.1007/s00520-019-05136-x Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Verhaak, Eline
Gehring, Karin
Hanssens, Patrick E. J.
Aaronson, Neil K.
Sitskoorn, Margriet M.
Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review
title Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review
title_full Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review
title_fullStr Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review
title_full_unstemmed Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review
title_short Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review
title_sort health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954134/
https://www.ncbi.nlm.nih.gov/pubmed/31792879
http://dx.doi.org/10.1007/s00520-019-05136-x
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