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Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen
The antigenic heterogeneity of the reticular framework of the white pulp and marginal zone is well documented in the human adult spleen. Immunostaining of α-smooth muscle actin characterizes the heterogeneity of the reticular framework of the white pulp and marginal zone. In the human spleen, the bl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JSLRT
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954172/ https://www.ncbi.nlm.nih.gov/pubmed/31866620 http://dx.doi.org/10.3960/jslrt.19032 |
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author | Satoh, Takashi Oikawa, Hiroki Yashima-Abo, Akiko Nishiya, Masao Masuda, Tomoyuki |
author_facet | Satoh, Takashi Oikawa, Hiroki Yashima-Abo, Akiko Nishiya, Masao Masuda, Tomoyuki |
author_sort | Satoh, Takashi |
collection | PubMed |
description | The antigenic heterogeneity of the reticular framework of the white pulp and marginal zone is well documented in the human adult spleen. Immunostaining of α-smooth muscle actin characterizes the heterogeneity of the reticular framework of the white pulp and marginal zone. In the human spleen, the blood cells flow in an open circulation. T and B lymphocytes flow out from the arterial terminal, and migrate in the reticular framework. Homing of lymphocytes to lymphoid tissues is regulated by selective interactions between cell surface homing receptors and tissue vascular addressins at sites of lymphocyte recruitment from the blood. In the present study, mucosal addressin cell adhesion molecule-1 was selectively expressed on α-smooth muscle actin-positive reticular framework. The reticular framework may function in lymphocyte homing and segregation into the periarteriolar lymphoid sheath, lymph follicle and marginal zone. |
format | Online Article Text |
id | pubmed-6954172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | JSLRT |
record_format | MEDLINE/PubMed |
spelling | pubmed-69541722020-01-13 Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen Satoh, Takashi Oikawa, Hiroki Yashima-Abo, Akiko Nishiya, Masao Masuda, Tomoyuki J Clin Exp Hematop Original Article The antigenic heterogeneity of the reticular framework of the white pulp and marginal zone is well documented in the human adult spleen. Immunostaining of α-smooth muscle actin characterizes the heterogeneity of the reticular framework of the white pulp and marginal zone. In the human spleen, the blood cells flow in an open circulation. T and B lymphocytes flow out from the arterial terminal, and migrate in the reticular framework. Homing of lymphocytes to lymphoid tissues is regulated by selective interactions between cell surface homing receptors and tissue vascular addressins at sites of lymphocyte recruitment from the blood. In the present study, mucosal addressin cell adhesion molecule-1 was selectively expressed on α-smooth muscle actin-positive reticular framework. The reticular framework may function in lymphocyte homing and segregation into the periarteriolar lymphoid sheath, lymph follicle and marginal zone. JSLRT 2019-12-22 /pmc/articles/PMC6954172/ /pubmed/31866620 http://dx.doi.org/10.3960/jslrt.19032 Text en © 2019 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License. |
spellingShingle | Original Article Satoh, Takashi Oikawa, Hiroki Yashima-Abo, Akiko Nishiya, Masao Masuda, Tomoyuki Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen |
title | Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen |
title_full | Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen |
title_fullStr | Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen |
title_full_unstemmed | Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen |
title_short | Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen |
title_sort | expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954172/ https://www.ncbi.nlm.nih.gov/pubmed/31866620 http://dx.doi.org/10.3960/jslrt.19032 |
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