A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

Developing insight into tissue-specific transcriptional mechanisms can help improve our understanding of how genetic variants exert their effects on complex traits and disease. In this study, we apply the principles of Mendelian randomization to systematically evaluate transcriptome-wide association...

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Detalles Bibliográficos
Autores principales: Richardson, Tom G., Hemani, Gibran, Gaunt, Tom R., Relton, Caroline L., Davey Smith, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954187/
https://www.ncbi.nlm.nih.gov/pubmed/31924771
http://dx.doi.org/10.1038/s41467-019-13921-9

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