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In vivo evidence of significant placental growth factor release by normal pregnancy placentas

Placental growth factor (PlGF) is an angiogenic factor identified in the maternal circulation, and a key biomarker for the diagnosis and management of placental disorders. Furthermore, enhancing the PlGF pathway is regarded as a promising therapy for preeclampsia. The source of PlGF is still controv...

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Autores principales: Cerdeira, Ana Sofia, Kandzija, Neva, Pargmae, Pille, Tome, Mariana, Zhang, Wei, Cooke, William R., Agrawal, Swati, James, Tim, Redman, Christopher, Vatish, Manu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954247/
https://www.ncbi.nlm.nih.gov/pubmed/31924819
http://dx.doi.org/10.1038/s41598-019-56906-w
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author Cerdeira, Ana Sofia
Kandzija, Neva
Pargmae, Pille
Tome, Mariana
Zhang, Wei
Cooke, William R.
Agrawal, Swati
James, Tim
Redman, Christopher
Vatish, Manu
author_facet Cerdeira, Ana Sofia
Kandzija, Neva
Pargmae, Pille
Tome, Mariana
Zhang, Wei
Cooke, William R.
Agrawal, Swati
James, Tim
Redman, Christopher
Vatish, Manu
author_sort Cerdeira, Ana Sofia
collection PubMed
description Placental growth factor (PlGF) is an angiogenic factor identified in the maternal circulation, and a key biomarker for the diagnosis and management of placental disorders. Furthermore, enhancing the PlGF pathway is regarded as a promising therapy for preeclampsia. The source of PlGF is still controversial with some believing it to be placental in origin while others refute this. To explore the source of PlGF, we undertook a prospective study enrolling normal pregnant women undergoing elective caesarean section. The level of PlGF was estimated in 17 paired serum samples from the uterine vein (ipsilateral or contralateral to the placental insertion) during caesarean section and from a peripheral vein on the same day and second day post-partum. PlGF levels were higher in the uterine than in the peripheral vein with a median difference of 52.2 (IQR 20.1–85.8) pg/mL p = 0.0006. The difference when the sampled uterine vein was ipsilateral to the placenta was 54.8 (IQR 37.1–88.4) pg/mL (n = 11) and 23.7 (IQR −11; 70.5) pg/mL (n = 6) when the sample was contralateral. Moreover, PlGF levels fell by 83% on day 1–2 post-partum. Our findings strongly support the primary source of PlGF to be placental. These findings will be of value in designing target therapies such as PlGF overexpression, to cure placental disorders during pregnancy.
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spelling pubmed-69542472020-01-15 In vivo evidence of significant placental growth factor release by normal pregnancy placentas Cerdeira, Ana Sofia Kandzija, Neva Pargmae, Pille Tome, Mariana Zhang, Wei Cooke, William R. Agrawal, Swati James, Tim Redman, Christopher Vatish, Manu Sci Rep Article Placental growth factor (PlGF) is an angiogenic factor identified in the maternal circulation, and a key biomarker for the diagnosis and management of placental disorders. Furthermore, enhancing the PlGF pathway is regarded as a promising therapy for preeclampsia. The source of PlGF is still controversial with some believing it to be placental in origin while others refute this. To explore the source of PlGF, we undertook a prospective study enrolling normal pregnant women undergoing elective caesarean section. The level of PlGF was estimated in 17 paired serum samples from the uterine vein (ipsilateral or contralateral to the placental insertion) during caesarean section and from a peripheral vein on the same day and second day post-partum. PlGF levels were higher in the uterine than in the peripheral vein with a median difference of 52.2 (IQR 20.1–85.8) pg/mL p = 0.0006. The difference when the sampled uterine vein was ipsilateral to the placenta was 54.8 (IQR 37.1–88.4) pg/mL (n = 11) and 23.7 (IQR −11; 70.5) pg/mL (n = 6) when the sample was contralateral. Moreover, PlGF levels fell by 83% on day 1–2 post-partum. Our findings strongly support the primary source of PlGF to be placental. These findings will be of value in designing target therapies such as PlGF overexpression, to cure placental disorders during pregnancy. Nature Publishing Group UK 2020-01-10 /pmc/articles/PMC6954247/ /pubmed/31924819 http://dx.doi.org/10.1038/s41598-019-56906-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cerdeira, Ana Sofia
Kandzija, Neva
Pargmae, Pille
Tome, Mariana
Zhang, Wei
Cooke, William R.
Agrawal, Swati
James, Tim
Redman, Christopher
Vatish, Manu
In vivo evidence of significant placental growth factor release by normal pregnancy placentas
title In vivo evidence of significant placental growth factor release by normal pregnancy placentas
title_full In vivo evidence of significant placental growth factor release by normal pregnancy placentas
title_fullStr In vivo evidence of significant placental growth factor release by normal pregnancy placentas
title_full_unstemmed In vivo evidence of significant placental growth factor release by normal pregnancy placentas
title_short In vivo evidence of significant placental growth factor release by normal pregnancy placentas
title_sort in vivo evidence of significant placental growth factor release by normal pregnancy placentas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954247/
https://www.ncbi.nlm.nih.gov/pubmed/31924819
http://dx.doi.org/10.1038/s41598-019-56906-w
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