Cargando…
Deciphering eukaryotic gene-regulatory logic with 100 million random promoters
How transcription factors (TFs) interpret cis-regulatory DNA sequence to control gene expression remains unclear, largely because past studies using native and engineered sequences had insufficient scale. Here, we measure the expression output of >100 million synthetic yeast promoter sequences th...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954276/ https://www.ncbi.nlm.nih.gov/pubmed/31792407 http://dx.doi.org/10.1038/s41587-019-0315-8 |