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Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly

The assembly of snRNP cores, in which seven Sm proteins, D1/D2/F/E/G/D3/B, form a ring around the nonameric Sm site of snRNAs, is the early step of spliceosome formation and essential to eukaryotes. It is mediated by the PMRT5 and SMN complexes sequentially in vivo. SMN deficiency causes neurodegene...

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Detalles Bibliográficos
Autores principales:	Yi, Hongfei, Mu, Li, Shen, Congcong, Kong, Xi, Wang, Yingzhi, Hou, Yan, Zhang, Rundong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954390/ https://www.ncbi.nlm.nih.gov/pubmed/31799625 http://dx.doi.org/10.1093/nar/gkz1135

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