Specific enhancer selection by IRF3, IRF5 and IRF9 is determined by ISRE half-sites, 5′ and 3′ flanking bases, collaborating transcription factors and the chromatin environment in a combinatorial fashion

IRF3, IRF5 and IRF9 are transcription factors, which play distinct roles in the regulation of antiviral and inflammatory responses. The determinants that mediate IRF-specific enhancer selection are not fully understood. To uncover regions occupied predominantly by IRF3, IRF5 or IRF9, we performed Ch...

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Detalles Bibliográficos
Autores principales: Csumita, Mária, Csermely, Attila, Horvath, Attila, Nagy, Gergely, Monori, Fanny, Göczi, Loránd, Orbea, Hans-Acha, Reith, Walter, Széles, Lajos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Data Resources and Analyses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954429/
https://www.ncbi.nlm.nih.gov/pubmed/31799619
http://dx.doi.org/10.1093/nar/gkz1112

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