Design of a programmable biosensor-CRISPRi genetic circuits for dynamic and autonomous dual-control of metabolic flux in Bacillus subtilis

Dynamic regulation is an effective strategy for fine-tuning metabolic pathways in order to maximize target product synthesis. However, achieving dynamic and autonomous up- and down-regulation of the metabolic modules of interest simultaneously, still remains a great challenge. In this work, we creat...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yaokang, Chen, Taichi, Liu, Yanfeng, Tian, Rongzhen, Lv, Xueqin, Li, Jianghua, Du, Guocheng, Chen, Jian, Ledesma-Amaro, Rodrigo, Liu, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954435/
https://www.ncbi.nlm.nih.gov/pubmed/31799627
http://dx.doi.org/10.1093/nar/gkz1123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954435/
https://www.ncbi.nlm.nih.gov/pubmed/31799627
http://dx.doi.org/10.1093/nar/gkz1123

Ejemplares similares