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Targeting reduced mitochondrial DNA quantity as a therapeutic approach in pediatric high-grade gliomas

BACKGROUND: Despite increased understanding of the genetic events underlying pediatric high-grade gliomas (pHGGs), therapeutic progress is static, with poor understanding of nongenomic drivers. We therefore investigated the role of alterations in mitochondrial function and developed an effective com...

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Detalles Bibliográficos
Autores principales:	Shen, Han, Yu, Man, Tsoli, Maria, Chang, Cecilia, Joshi, Swapna, Liu, Jie, Ryall, Scott, Chornenkyy, Yevgen, Siddaway, Robert, Hawkins, Cynthia, Ziegler, David S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Pediatric Neuro-Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954438/ https://www.ncbi.nlm.nih.gov/pubmed/31398252 http://dx.doi.org/10.1093/neuonc/noz140

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