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Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization

The Spinal Muscular Atrophy (SMA) gene SMN was recently duplicated (SMN1 and SMN2) in higher primates. Furthermore, invasion of the locus by repetitive elements almost doubled its size with respect to mouse Smn, in spite of an almost identical protein-coding sequence. Herein, we found that SMN ranks...

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Detalles Bibliográficos
Autores principales:	Pagliarini, Vittoria, Jolly, Ariane, Bielli, Pamela, Di Rosa, Valentina, De la Grange, Pierre, Sette, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954450/ https://www.ncbi.nlm.nih.gov/pubmed/31777926 http://dx.doi.org/10.1093/nar/gkz1117

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