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Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis
BACKGROUND: To evaluate the prognostic value of pretreatment lymphocyte counts with respect to clinical outcomes in patients with solid tumors. METHODS: Systematic literature search of electronic databases (Pubmed, Embase and Web of Science) up to May 1, 2018 was carried out by two independent revie...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954501/ https://www.ncbi.nlm.nih.gov/pubmed/31938023 http://dx.doi.org/10.1186/s12935-020-1094-5 |
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author | Zhao, Jiawen Huang, Weijia Wu, Yongxian Luo, Yihuan Wu, Bo Cheng, Jiwen Chen, Junqiang Liu, Deyun Li, Chengyang |
author_facet | Zhao, Jiawen Huang, Weijia Wu, Yongxian Luo, Yihuan Wu, Bo Cheng, Jiwen Chen, Junqiang Liu, Deyun Li, Chengyang |
author_sort | Zhao, Jiawen |
collection | PubMed |
description | BACKGROUND: To evaluate the prognostic value of pretreatment lymphocyte counts with respect to clinical outcomes in patients with solid tumors. METHODS: Systematic literature search of electronic databases (Pubmed, Embase and Web of Science) up to May 1, 2018 was carried out by two independent reviewers. We included Eligible studies assessed the prognostic impact of pretreatment lymphocytes and had reported hazard ratios (HR) with 95% confidence intervals (CIs) for endpoints including overall survival (OS) and progression-free survival (PFS). Only English publications were included. RESULTS: A total of 42 studies comprising 13,272 patients were included in this systematic review and meta-analysis. Low pretreatment lymphocyte count was associated with poor OS (HR = 1.27, 95% CI 1.16–1.39, P < 0.001, I(2) = 58.5%) and PFS (HR = 1.27, 95% CI 1.15–1.40, P < 0.001, I(2) = 25.7%). Subgroup analysis disaggregated by cancer type indicated that low pretreatment lymphocytes were most closely associated with poor OS in colorectal cancer followed by breast cancer and renal cancer. CONCLUSIONS: Low pretreatment lymphocyte count may represent an unfavorable prognostic factor for clinical outcomes in patients with solid tumors. |
format | Online Article Text |
id | pubmed-6954501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69545012020-01-14 Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis Zhao, Jiawen Huang, Weijia Wu, Yongxian Luo, Yihuan Wu, Bo Cheng, Jiwen Chen, Junqiang Liu, Deyun Li, Chengyang Cancer Cell Int Primary Research BACKGROUND: To evaluate the prognostic value of pretreatment lymphocyte counts with respect to clinical outcomes in patients with solid tumors. METHODS: Systematic literature search of electronic databases (Pubmed, Embase and Web of Science) up to May 1, 2018 was carried out by two independent reviewers. We included Eligible studies assessed the prognostic impact of pretreatment lymphocytes and had reported hazard ratios (HR) with 95% confidence intervals (CIs) for endpoints including overall survival (OS) and progression-free survival (PFS). Only English publications were included. RESULTS: A total of 42 studies comprising 13,272 patients were included in this systematic review and meta-analysis. Low pretreatment lymphocyte count was associated with poor OS (HR = 1.27, 95% CI 1.16–1.39, P < 0.001, I(2) = 58.5%) and PFS (HR = 1.27, 95% CI 1.15–1.40, P < 0.001, I(2) = 25.7%). Subgroup analysis disaggregated by cancer type indicated that low pretreatment lymphocytes were most closely associated with poor OS in colorectal cancer followed by breast cancer and renal cancer. CONCLUSIONS: Low pretreatment lymphocyte count may represent an unfavorable prognostic factor for clinical outcomes in patients with solid tumors. BioMed Central 2020-01-10 /pmc/articles/PMC6954501/ /pubmed/31938023 http://dx.doi.org/10.1186/s12935-020-1094-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Primary Research Zhao, Jiawen Huang, Weijia Wu, Yongxian Luo, Yihuan Wu, Bo Cheng, Jiwen Chen, Junqiang Liu, Deyun Li, Chengyang Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis |
title | Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis |
title_full | Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis |
title_fullStr | Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis |
title_full_unstemmed | Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis |
title_short | Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis |
title_sort | prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954501/ https://www.ncbi.nlm.nih.gov/pubmed/31938023 http://dx.doi.org/10.1186/s12935-020-1094-5 |
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