VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice

BACKGROUND: Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF levels correlate with mean amyloid plaque density, Clinical Dementia Rating (CDR)...

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Detalles Bibliográficos
Autores principales: El Gaamouch, Farida, Audrain, Mickael, Lin, Wei-Jye, Beckmann, Noam, Jiang, Cheng, Hariharan, Siddharth, Heeger, Peter S., Schadt, Eric E., Gandy, Sam, Ehrlich, Michelle E., Salton, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954537/
https://www.ncbi.nlm.nih.gov/pubmed/31924226
http://dx.doi.org/10.1186/s13024-020-0357-x

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