The stability of blood Eosinophils in chronic obstructive pulmonary disease

Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 a...

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Autores principales: Long, Gabriella H., Southworth, Thomas, Kolsum, Umme, Donaldson, Gavin C., Wedzicha, Jadwiga A., Brightling, Christopher E., Singh, Dave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954589/
https://www.ncbi.nlm.nih.gov/pubmed/31924207
http://dx.doi.org/10.1186/s12931-020-1279-4
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author Long, Gabriella H.
Southworth, Thomas
Kolsum, Umme
Donaldson, Gavin C.
Wedzicha, Jadwiga A.
Brightling, Christopher E.
Singh, Dave
author_facet Long, Gabriella H.
Southworth, Thomas
Kolsum, Umme
Donaldson, Gavin C.
Wedzicha, Jadwiga A.
Brightling, Christopher E.
Singh, Dave
author_sort Long, Gabriella H.
collection PubMed
description Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.
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spelling pubmed-69545892020-01-14 The stability of blood Eosinophils in chronic obstructive pulmonary disease Long, Gabriella H. Southworth, Thomas Kolsum, Umme Donaldson, Gavin C. Wedzicha, Jadwiga A. Brightling, Christopher E. Singh, Dave Respir Res Letter to the Editor Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds. BioMed Central 2020-01-10 2020 /pmc/articles/PMC6954589/ /pubmed/31924207 http://dx.doi.org/10.1186/s12931-020-1279-4 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Long, Gabriella H.
Southworth, Thomas
Kolsum, Umme
Donaldson, Gavin C.
Wedzicha, Jadwiga A.
Brightling, Christopher E.
Singh, Dave
The stability of blood Eosinophils in chronic obstructive pulmonary disease
title The stability of blood Eosinophils in chronic obstructive pulmonary disease
title_full The stability of blood Eosinophils in chronic obstructive pulmonary disease
title_fullStr The stability of blood Eosinophils in chronic obstructive pulmonary disease
title_full_unstemmed The stability of blood Eosinophils in chronic obstructive pulmonary disease
title_short The stability of blood Eosinophils in chronic obstructive pulmonary disease
title_sort stability of blood eosinophils in chronic obstructive pulmonary disease
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954589/
https://www.ncbi.nlm.nih.gov/pubmed/31924207
http://dx.doi.org/10.1186/s12931-020-1279-4
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