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Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes

BACKGROUND: Glycemia is related to energy production during exercise. Coenzyme Q10 is an antioxidant that participates in adenosine triphosphate synthesis in mitochondria. The aim of this study was to investigate the level of coenzyme Q10, glucose parameters, and antioxidant capacity in athletes. ME...

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Autores principales: Ho, Chien-Chang, Tseng, Ching-Yu, Chen, Hung-Wun, Chiu, Yi-Wen, Tsai, Ming-Chih, Chang, Po-Sheng, Lin, Ping-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954618/
https://www.ncbi.nlm.nih.gov/pubmed/31924223
http://dx.doi.org/10.1186/s12970-020-0334-3
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author Ho, Chien-Chang
Tseng, Ching-Yu
Chen, Hung-Wun
Chiu, Yi-Wen
Tsai, Ming-Chih
Chang, Po-Sheng
Lin, Ping-Ting
author_facet Ho, Chien-Chang
Tseng, Ching-Yu
Chen, Hung-Wun
Chiu, Yi-Wen
Tsai, Ming-Chih
Chang, Po-Sheng
Lin, Ping-Ting
author_sort Ho, Chien-Chang
collection PubMed
description BACKGROUND: Glycemia is related to energy production during exercise. Coenzyme Q10 is an antioxidant that participates in adenosine triphosphate synthesis in mitochondria. The aim of this study was to investigate the level of coenzyme Q10, glucose parameters, and antioxidant capacity in athletes. METHODS: This study was designed as a cross-sectional study. Well-trained college athletes (n = 43) and age-gender matched healthy subjects (n = 25) were recruited from a college. The levels of glucose parameters, oxidative stress, antioxidant enzymes activity, Trolox equivalent antioxidant capacity (TAC), and coenzyme Q10 status were measured in the present study. RESULTS: The athletes had a significantly lower level of white blood cells (WBC) coenzyme Q10 than the healthy subjects (0.34 ± 0.24 vs. 0.65 ± 0.43 nmol/g, p < 0.01); however, no significant difference was detected in plasma coenzyme Q10 between the two groups. Regarding the glucose parameters, the athletes had significantly higher values for HbA1c (5.5 ± 0.3 vs. 5.3 ± 0.3%, p < 0.05) and quantitative insulin sensitivity check index (QUICKI, 0.37 ± 0.03 vs. 0.34 ± 0.03, p < 0.05), and lower homeostatic model assessment-insulin resistance (HOMA-IR, 1.5 ± 0.8 vs. 2.9 ± 3.8, p < 0.05) than the healthy subjects. A higher level of TAC was found in the athletes (serum, 5.7 ± 0.3 vs. 5.4 ± 0.2 mM Trolox; erythrocyte, 10.5 ± 0.6 vs. 10.0 ± 0.5 mM Trolox, p < 0.05). In addition, WBC coenzyme Q10 status was significantly correlated with catalase activity (r = 0.56, p < 0.01), GPx activity (r = 0.56, p < 0.01), serum TAC (r = 0.54, p < 0.01), fasting glucose (β = − 1.10, p < 0.01), HbA1c (β = − 0.82, p < 0.01), HOMA-IR (β = − 1.81, p < 0.01), and QUICK (β = 0.08, p < 0.01). CONCLUSIONS: Athletes may suffer from a marginal coenzyme Q10 deficiency, and the level was related to glycemic control and antioxidant capacity. Further interventional studies are needed to clarify an adequate dose of coenzyme Q10 supplementation in athletes to optimize their coenzyme Q10 status and athletic performance or recovery during exercise.
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spelling pubmed-69546182020-01-14 Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes Ho, Chien-Chang Tseng, Ching-Yu Chen, Hung-Wun Chiu, Yi-Wen Tsai, Ming-Chih Chang, Po-Sheng Lin, Ping-Ting J Int Soc Sports Nutr Research Article BACKGROUND: Glycemia is related to energy production during exercise. Coenzyme Q10 is an antioxidant that participates in adenosine triphosphate synthesis in mitochondria. The aim of this study was to investigate the level of coenzyme Q10, glucose parameters, and antioxidant capacity in athletes. METHODS: This study was designed as a cross-sectional study. Well-trained college athletes (n = 43) and age-gender matched healthy subjects (n = 25) were recruited from a college. The levels of glucose parameters, oxidative stress, antioxidant enzymes activity, Trolox equivalent antioxidant capacity (TAC), and coenzyme Q10 status were measured in the present study. RESULTS: The athletes had a significantly lower level of white blood cells (WBC) coenzyme Q10 than the healthy subjects (0.34 ± 0.24 vs. 0.65 ± 0.43 nmol/g, p < 0.01); however, no significant difference was detected in plasma coenzyme Q10 between the two groups. Regarding the glucose parameters, the athletes had significantly higher values for HbA1c (5.5 ± 0.3 vs. 5.3 ± 0.3%, p < 0.05) and quantitative insulin sensitivity check index (QUICKI, 0.37 ± 0.03 vs. 0.34 ± 0.03, p < 0.05), and lower homeostatic model assessment-insulin resistance (HOMA-IR, 1.5 ± 0.8 vs. 2.9 ± 3.8, p < 0.05) than the healthy subjects. A higher level of TAC was found in the athletes (serum, 5.7 ± 0.3 vs. 5.4 ± 0.2 mM Trolox; erythrocyte, 10.5 ± 0.6 vs. 10.0 ± 0.5 mM Trolox, p < 0.05). In addition, WBC coenzyme Q10 status was significantly correlated with catalase activity (r = 0.56, p < 0.01), GPx activity (r = 0.56, p < 0.01), serum TAC (r = 0.54, p < 0.01), fasting glucose (β = − 1.10, p < 0.01), HbA1c (β = − 0.82, p < 0.01), HOMA-IR (β = − 1.81, p < 0.01), and QUICK (β = 0.08, p < 0.01). CONCLUSIONS: Athletes may suffer from a marginal coenzyme Q10 deficiency, and the level was related to glycemic control and antioxidant capacity. Further interventional studies are needed to clarify an adequate dose of coenzyme Q10 supplementation in athletes to optimize their coenzyme Q10 status and athletic performance or recovery during exercise. BioMed Central 2020-01-10 /pmc/articles/PMC6954618/ /pubmed/31924223 http://dx.doi.org/10.1186/s12970-020-0334-3 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ho, Chien-Chang
Tseng, Ching-Yu
Chen, Hung-Wun
Chiu, Yi-Wen
Tsai, Ming-Chih
Chang, Po-Sheng
Lin, Ping-Ting
Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes
title Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes
title_full Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes
title_fullStr Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes
title_full_unstemmed Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes
title_short Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes
title_sort coenzyme q10 status, glucose parameters, and antioxidative capacity in college athletes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954618/
https://www.ncbi.nlm.nih.gov/pubmed/31924223
http://dx.doi.org/10.1186/s12970-020-0334-3
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