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Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is an irreversible, neurodegenerative disease that is characterized by memory impairment and executive dysfunction. However, the change of fine structure of neuronal morphology remains unclear in the AD model mouse. In this study, high-resolution mouse brain sectional images...

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Autores principales: Zhang, Yu, Xiao, Zhenlong, He, Zhijun, Chen, Junyu, Wang, Xin, Jiang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955100/
https://www.ncbi.nlm.nih.gov/pubmed/31942251
http://dx.doi.org/10.7717/peerj.8178
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author Zhang, Yu
Xiao, Zhenlong
He, Zhijun
Chen, Junyu
Wang, Xin
Jiang, Liang
author_facet Zhang, Yu
Xiao, Zhenlong
He, Zhijun
Chen, Junyu
Wang, Xin
Jiang, Liang
author_sort Zhang, Yu
collection PubMed
description Alzheimer’s disease (AD) is an irreversible, neurodegenerative disease that is characterized by memory impairment and executive dysfunction. However, the change of fine structure of neuronal morphology remains unclear in the AD model mouse. In this study, high-resolution mouse brain sectional images were scanned by Micro-Optical Sectioning Tomography (MOST) technology and reconstructed three-dimensionally to obtain the pyramidal neurons. The method of Sholl analysis was performed to analyze the neurons in the brains of 6- and 12-month-old AD mice. The results showed that dendritic complexity was not affected in the entorhinal cortex between 6-month-old mice and 12-month-old mice. The dendritic complexity had increased in the primary motor cortex and CA1 region of hippocampus of 12- month-old mice compared with 6-month-old mice. On the contrary, dendritic complexity in the prefrontal cortex was decreased significantly between 6-month-old and 12-month-old mice. To our knowledge, this is the first study to provide high-resolution brain images of triple transgenic AD mice for statistically analyzing neuronal dendrite complexity by MOST technology to reveal the morphological changes of neurons during AD progression.
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spelling pubmed-69551002020-01-15 Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease Zhang, Yu Xiao, Zhenlong He, Zhijun Chen, Junyu Wang, Xin Jiang, Liang PeerJ Bioinformatics Alzheimer’s disease (AD) is an irreversible, neurodegenerative disease that is characterized by memory impairment and executive dysfunction. However, the change of fine structure of neuronal morphology remains unclear in the AD model mouse. In this study, high-resolution mouse brain sectional images were scanned by Micro-Optical Sectioning Tomography (MOST) technology and reconstructed three-dimensionally to obtain the pyramidal neurons. The method of Sholl analysis was performed to analyze the neurons in the brains of 6- and 12-month-old AD mice. The results showed that dendritic complexity was not affected in the entorhinal cortex between 6-month-old mice and 12-month-old mice. The dendritic complexity had increased in the primary motor cortex and CA1 region of hippocampus of 12- month-old mice compared with 6-month-old mice. On the contrary, dendritic complexity in the prefrontal cortex was decreased significantly between 6-month-old and 12-month-old mice. To our knowledge, this is the first study to provide high-resolution brain images of triple transgenic AD mice for statistically analyzing neuronal dendrite complexity by MOST technology to reveal the morphological changes of neurons during AD progression. PeerJ Inc. 2020-01-09 /pmc/articles/PMC6955100/ /pubmed/31942251 http://dx.doi.org/10.7717/peerj.8178 Text en ©2020 Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioinformatics
Zhang, Yu
Xiao, Zhenlong
He, Zhijun
Chen, Junyu
Wang, Xin
Jiang, Liang
Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
title Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
title_full Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
title_fullStr Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
title_full_unstemmed Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
title_short Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
title_sort dendritic complexity change in the triple transgenic mouse model of alzheimer’s disease
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955100/
https://www.ncbi.nlm.nih.gov/pubmed/31942251
http://dx.doi.org/10.7717/peerj.8178
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