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Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression

Mutant p53 (R248Q) induces doxorubicin (ADM) resistance in hepatocellular carcinoma (HCC). Dihydroartemisinin (DHA) can synergistically enhance anticancer effect of many chemotherapeutic agents. However, whether DHA could increase therapeutic efficacy of ADM in p53 (R248Q)-expressing HCC cells remai...

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Detalles Bibliográficos
Autores principales:	Yang, Yue, He, Jianxin, Chen, Jing, Lin, Li, Liu, Yongqi, Zhou, Cunmin, Su, Yun, Wei, Hulai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955115/ https://www.ncbi.nlm.nih.gov/pubmed/31976328 http://dx.doi.org/10.1155/2019/8207056

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