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No Severe Adverse Effects from Intravitreally Injected Putative Adipose Tissue-Derived Stem Cells

This study reports findings from a 56-year-old patient, who had received bilateral intravitreal injection of putative adipose tissue-derived stem cells at a private clinic in India with the promise of treatment of NAION. During an observation period of 8, respectively, 18 months, the intravitreally...

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Detalles Bibliográficos
Autores principales: Faber, Carsten, Heegaard, Steffen, Kiilgaard, Jens Folke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955138/
https://www.ncbi.nlm.nih.gov/pubmed/31976105
http://dx.doi.org/10.1155/2019/6927829
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author Faber, Carsten
Heegaard, Steffen
Kiilgaard, Jens Folke
author_facet Faber, Carsten
Heegaard, Steffen
Kiilgaard, Jens Folke
author_sort Faber, Carsten
collection PubMed
description This study reports findings from a 56-year-old patient, who had received bilateral intravitreal injection of putative adipose tissue-derived stem cells at a private clinic in India with the promise of treatment of NAION. During an observation period of 8, respectively, 18 months, the intravitreally injected cells remained silent in the vitreous bodies without either therapeutic effects or complications. The cells cleared with vitrectomy without evidence of integration in the optic nerve or retina. Contrary to recent reports on patients receiving intravitreal injections of similar putative stem cells with the aim of treating AMD, our patient suffered no devastating ocular consequences. Summary. Contrary to recent reports, this case demonstrated no devastating consequences of intravitreal injection of adipose tissue-derived stem cells during an observation period of up to 18 months. After vitrectomy, the cells cleared without evidence of either harm or integration.
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spelling pubmed-69551382020-01-23 No Severe Adverse Effects from Intravitreally Injected Putative Adipose Tissue-Derived Stem Cells Faber, Carsten Heegaard, Steffen Kiilgaard, Jens Folke Case Rep Ophthalmol Med Case Report This study reports findings from a 56-year-old patient, who had received bilateral intravitreal injection of putative adipose tissue-derived stem cells at a private clinic in India with the promise of treatment of NAION. During an observation period of 8, respectively, 18 months, the intravitreally injected cells remained silent in the vitreous bodies without either therapeutic effects or complications. The cells cleared with vitrectomy without evidence of integration in the optic nerve or retina. Contrary to recent reports on patients receiving intravitreal injections of similar putative stem cells with the aim of treating AMD, our patient suffered no devastating ocular consequences. Summary. Contrary to recent reports, this case demonstrated no devastating consequences of intravitreal injection of adipose tissue-derived stem cells during an observation period of up to 18 months. After vitrectomy, the cells cleared without evidence of either harm or integration. Hindawi 2019-12-31 /pmc/articles/PMC6955138/ /pubmed/31976105 http://dx.doi.org/10.1155/2019/6927829 Text en Copyright © 2019 Carsten Faber et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Faber, Carsten
Heegaard, Steffen
Kiilgaard, Jens Folke
No Severe Adverse Effects from Intravitreally Injected Putative Adipose Tissue-Derived Stem Cells
title No Severe Adverse Effects from Intravitreally Injected Putative Adipose Tissue-Derived Stem Cells
title_full No Severe Adverse Effects from Intravitreally Injected Putative Adipose Tissue-Derived Stem Cells
title_fullStr No Severe Adverse Effects from Intravitreally Injected Putative Adipose Tissue-Derived Stem Cells
title_full_unstemmed No Severe Adverse Effects from Intravitreally Injected Putative Adipose Tissue-Derived Stem Cells
title_short No Severe Adverse Effects from Intravitreally Injected Putative Adipose Tissue-Derived Stem Cells
title_sort no severe adverse effects from intravitreally injected putative adipose tissue-derived stem cells
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955138/
https://www.ncbi.nlm.nih.gov/pubmed/31976105
http://dx.doi.org/10.1155/2019/6927829
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