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Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
A unique property of skeletal muscle is its ability to adapt its mass to changes in activity. Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength, leading to physical incapacity and poor quality of life. Here, through a combination of transcriptomics and transgene...
Autores principales: | Segalés, Jessica, Perdiguero, Eusebio, Serrano, Antonio L., Sousa-Victor, Pedro, Ortet, Laura, Jardí, Mercè, Budanov, Andrei V., Garcia-Prat, Laura, Sandri, Marco, Thomson, David M., Karin, Michael, Hee Lee, Jun, Muñoz-Cánoves, Pura |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955241/ https://www.ncbi.nlm.nih.gov/pubmed/31929511 http://dx.doi.org/10.1038/s41467-019-13832-9 |
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